摘要
和厚扑酚是中药厚朴中分离的带有烯丙基的连苯二酚类化合物,具有广泛的药理作用,包括抗炎、抗菌、抗血小板凝集、保护心脑血管系统作用、抗焦虑、抗癫痫、肌肉松弛、抗氧化、抗肿瘤、改善胃肠功能紊乱及抗肿瘤作用等。因和厚朴酚毒性较低,其抗肿瘤作用成为近年研究的热点。它具有诱导肿瘤细胞凋亡、促进肿瘤细胞分化、抑制肿瘤细胞增殖、抑制肿瘤转移、抗肿瘤血管形成、逆转肿瘤多药耐药等作用。本文对其药理作用及抗肿瘤机制进行综述。
Honokiol is isolated from traditional Chinese medicine magnolia bark which has Allyl connection with hydroquinone compounds,with a wide range of pharmacological effects, including antiinflammatory, antibacterial, anti-platelet aggregation, anti-anxiety, epilepsy, muscle relaxants, anti-oxidation, anti-tumor,protects cardiovascular and cerebrovascular systems. Honokiol by a much less toxic, and its anti-tumor effect become a research hotspet in recent years. It can induce tumor cell apoptosis and promote tumor cell differentiation, inhibit tumor cell proliferation and metastasis, anti-tumor angiogenesis, tumor multidrug resistance reversal effects. In this paper, its pharmacological effects and mechanism of anti-tumor were reviewed.
出处
《医学综述》
2009年第11期1725-1727,共3页
Medical Recapitulate
关键词
和厚朴酚
药理作用
肿瘤
Honokiol
Pharmacological action
Tumor
