摘要
目的比较福辛普利与依那普利治疗轻中度高血压病的疗效和安全性。方法随机开放对照试验，经２周安慰剂导入期，１３９例轻中度高血压患者进入８周治疗期，每日１次服用福辛普利１０ｍｇ（７４例）或依那普利５ｍｇ（６５例），２周后如舒张压≥９０ｍｍＨｇ则剂量加倍，４周后如仍无效则每日加服双氢克尿噻２５ｍｇ。结果两组药物均能明显降低血压（Ｐ＜０．００１）；福辛普利有效率９０１％，依那普利有效率８８９％（Ｐ＞０．０５）。福辛普利和依那普利组分别有３８％和５１％患者加用利尿剂（Ｐ＞０．０５）。福辛普利降压谷峰值比率５９９％，依那普利为４７１％。最常见不良反应是咳嗽，两组各４例。结论对轻中度高血压病福辛普利是一种有效、安全且易耐受的降压药。
Objective To compare the efficacy and safety of fosinopril and enalapril in the treatment of mild to moderate hypertension. Methods Following a 2 week placebo period, 139 patients entered an 8 week randomized, parallel study with either 10 mg fosinopril ( n =74) or 5 mg enalapril ( n =65) once daily. Dose doubling and the addition of dihydrochlorothiazide 25 mg once daily were required if diastolic blood pressure ≥90 mmHg at week 2 and week 4 respectively. Results Blood pressure were significantly reduced in both groups ( P <0.001) . There was no significant difference in responder rates between fosinopril treated patients (90.1%) and patients taking enalapril (88.9%). The addition of diuretic was required in 38% of patients on fosinopril and 51% of patients on enalapril. The trough to peak ratios were calculated as 59.9% for fosinopril and 47.1% for enalapril. Cough was the most common side effect, observed in 4 patients in each group. Conclusion Fosinopril once daily is effective, safe and well tolerated in mild to moderate hypertensive patients.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
1998年第3期193-195,共3页
Chinese Journal of Cardiology
