摘要
目的研究血清抗环瓜氨酸肽(CCP)抗体用于丙型肝炎病毒(HCV)相关性关节病与类风湿性关节炎(RA)鉴别诊断的可能性。方法采用ELISA和免疫比浊的方法分别检测了45例慢性丙型肝炎(CHC)患者血清抗CCP抗体及类风湿因子(RF)的水平,并与RA患者及正常对照组的检测结果进行比较。结果正常对照组未检测到抗CCP抗体,RF的阳性率(6.7%)也较低。而RA患者的抗CCP抗体和RF阳性率均较高,分别达80.0%和93.3%。CHC患者血清RF阳性率亦明显高于正常对照组(P<0.01),但CHC患者血清抗CCP抗体滴度大多小于10U/ml,低于试剂盒提供的cutoff值,阳性率远低于RA组(P<0.01)。结论抗CCP抗体可用于HCV相关性关节病与RA的鉴别诊断。
Objective To investigate the clinical significance of detecting serum anti-CCP antibodies in discrimining the patients with rheumatoid arthritis（RA） and with chronic hepatitis C virus （ HCV）-associated arthropathy. Methods Anti-Cyclic citrulline peptide （CCP） antibody and rheumatoid factor（RF） levels in serum of the patients with HCV infection were determined by ELISA method,which were compared with those of healthy controls and of the patients with RA. Results No anti-CCP antibody and low RF（6.7%） were detected in 30 healthy subjects, which were found in high levels in RA patients （80.0% and 93.3%, respectively）. The positive percentage of anti-CCP antibodies in patients with chronic HCV infection（CHC） was significantly lower than that in healthy controls （P〈0.01）. But titre of anti-CCP antibodies in majolity CHC patients was less than 10 U/ml and less than the cutoff value of the cortmercial box. The RF positive rate of CHC patients was far lower than that of RA patients （P〈0.01）. Conclusion Detection of serum anti-CCP may be taken as an useful tool for discriminating the patients with RA from those with HCV-associated arthropathy.
出处
《江苏医药》
CAS
CSCD
北大核心
2009年第6期624-625,共2页
Jiangsu Medical Journal
基金
江苏省高校自然科学研究指导性计划(07KJD320033)
