摘要
目的:构建视神经视觉假体反馈系统,寻求在体测量刺激电极-视神经联合阻抗的方法,使之作为在体情况下评估刺激电极状态的依据。方法:分析电极-视神经的阻抗模型,利用刺激器的双向脉冲刺激电流作为电极-视神经阻抗的载体,采用三电极阻抗测量法对电极-视神经的阻抗进行在体测量。结果:在误差允许的范围内,本试验构建的反馈系统能够在视神经视觉假体刺激的同时,测量出刺激电极间的电极-视神经阻抗。结论:在不改变测量信号发生器的情况下,可以利用微电流刺激器产生的刺激电流作为阻抗的测量信号,此种方法既不增加假体装置的规模,又能取得较精确的测量结果。
Objective： To constitute a feedback system for optic nerve prosthesis and choose a method to measure the electrode-optic nerve impedance, which could be used to evaluate the condition of stimulation electrodes. Methods： This paper describes an electrode-optic nerve impedance model firstly, and then adopts three-electrode measurement method to measure the electrode-optic nerve impedance with stimulation current as measurement current. Results： Experimental results show that in the range of allowable error, the method is available in electrode-optic nerve impedance measurement. Conclusion： Electrode-optic nerve impedance could be achieved precisely by micro-stimulator without additional signal synthesizer.
出处
《中国医学物理学杂志》
CSCD
2009年第3期1184-1187,1209,共5页
Chinese Journal of Medical Physics
基金
国家重点基础研究发展计划(No.2005CB724302)
国家自然基金杰出青年科学基金(No.60588101)
国家863计划资助项目(No.2006AA04Z356)
上海市科委科研计划项目(No.064119540)
关键词
视神经视觉假体
反馈系统
电极-视神经阻抗模型
在体阻抗测量
neural prosthesis
feedback system
electrode-optic nerve impedance model
in-vivo measurement of impedance
