摘要
巨细胞病毒(CMV)是肾移植术后最重要的致病微生物之一,CMV感染对肾移植受者可能导致的直接影响如CMV肺炎、肠炎及肝炎等为人熟知;而对肾移植受者的间接影响多被低估,包括移植肾排斥、继发感染(细菌、真菌和二次病毒感染)、恶性肿瘤、移植后糖尿病、心血管并发症、淋巴细胞增生病(PTLD)以及人、肾存活率下降等。肾移植受者术前透析及术后应用免疫抑制剂,会显著增加CMV感染途径及感染风险,使原发感染和潜伏感染被重新激活的可能性增加,引起一系列不良反应;因此,对于肾移植受者CMV感染的早期诊断和防治至关重要。对于CMV感染的防治策略,目前倾向采用早期优先治疗和预防性治疗。
Cytomegalovirus（CMV） is one of the most important pathogenic microorganisms after renal transplantation. The possible direct effects of CMV infection such as CMV pneumonia, enteritis and hepatitis are well learned. However, the indirect effects caused by CMV infection including graft rejection, secondary infection （bacteria, fungi and secondary virus infection）, malignant tumor, posttransplant diabetes mellitus, cardiovascular disease, posttransplant lymphoproliferative disease and decrease of survival rate of receptors and grafts are underestimated. Hemodialysis before operation and immunosuppressant usage after transplantation may increase the risk of CMV infection, add to the possibility of activation of primary infection and latent infection, and lead to a series of adverse effects among the renal receptors. So it is of great importance for the early diagnosis and treatment of CMV infection. For the prevention and treatment of CMV infection, the preemptive therapy and prophylactic treatment are advised.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2009年第5期589-593,共5页
Journal of Shanghai Jiao tong University:Medical Science
关键词
巨细胞病毒
肾移植
间接损害
预防性治疗
早期优先治疗
cytomegalovirus
renal transplantation
indirect impairment
prophylactic treatment
preemptive therapy
