摘要
采用目前常用的醋酸氢化可的松致肾虚模型和大黄致脾虚模型，比较了传统经典方剂肾气汤（丸）和四君子汤对模型动物的淋巴细胞转化率、ＮＫ细胞活性、白介素１（ＩＬ－１）和溶血抗体产生能力的作用。结果表明，肾虚和脾虚模型动物免疫功能皆有显著下降（Ｐ＜０．０１，Ｐ＜０．０５），肾虚尤为明显。肾气汤对肾虚和脾虚模型均有明显的治疗作用（Ｐ＜０．０５），而四君子汤仅对脾虚模型有治疗作用。推测两种模型的成因和两种方剂的作用机理有所不同，同时提示如果在脾虚健脾治疗无效时。
Kidney_deficiency animal model (KDAM) induced by hydrocortisone acetate and spleen_deficiency animal model (SDAM) by et Rhdix et Rhizoma Rhei were used for the study. The effects of two classic formulae, Shenqi Decoction (SQ) and Sijunzi Decoction (SJZ) on the lymphocyte transformation rate, NK cell activity, IL_1 and hemolytic antibody were compared. The results showed that the immune function of KDAM and SDAM decreased significantly (P<0.01,P< 0.05), KDAM being more obvious. SQ exerted a therapeutic effect on KDAM and SDAM, while SJZ only on SDAM. It is suggested that the two kinds of animal models possess the different formative causes and the mechanisms of two formulae are various, and kidney-invigorating therapy can be adopted when spleen-strengthening therapy fails in the treatment of spleen deficiency.
出处
《中药新药与临床药理》
CAS
CSCD
1998年第2期84-86,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
广东省自然科学基金
关键词
肾虚
免疫学
脾虚
肾气丸
药理学
四君子汤
kidney deficiency/immunol.
spleen deficiency/immunol.
kidney deficiency/TCD therapy
spleen deficiency/TCD therapy
Shenqi Decoction/pharmacol
Sijunzi Decoction/pharmacol.
disease models, animal
