摘要
为了研究血清ＩＣＴＰ、ＰＩＣＰ和ＰＩＩＮＰ的水平与原发性肝癌骨转移的关系，采用放射免疫法检测了５０例原发性肝癌（骨转移３０例，无骨转移２０例）及２０例健康者血清中ＩＣＴＰ、ＰＩＣＰ和ＰＩＮＰ的水平，结果发现，原发性肝癌患者血清ＩＣＴＰ、ＰＩＮＰ显著高于健康者（Ｐ＜０．０１和Ｐ＜０．０５），其中伴骨转移的原发性肝癌血清ＩＣＴＰ、ＰＩＮＰ显著高于无骨转移者（Ｐ＜０．０１），但ＰＩＣＰ则无显著性差异，提示ＩＣＴＰ和ＰＩＮＰ可作为原发性肝癌的预后判断指标，尤其可作为原发性肝癌发生骨转移的判断指标。
In order to investigate the relationship between ICTP, PICP, PIINP and bone metastasis of primary hepatic cancer(PHC), The serum concentration of ICTP, PICP, and PIINP were detected in 50 casea of PHC(30 cases with bone metastasis, 20 cases without bone metasasis) and 20 normal controls by using the radioimmunoassay. The ICTP and PIINP in PHC were significantly higher than that in normal controls( P <0.01 and P <0.05). The level of ICTP and PIINP in bone metastasis group were significantly higher than that without bone metastasis ( P <0.01). The ICTP and PIINP decreased remarkably after chemotherapy in bone metastasis group ( P <0.05). The results suggested that the ICTP and PIINP may be as prognostic markers for evaluation of PHC, espically for PHC with bone metastasis.
出处
《肿瘤研究与临床》
CAS
1998年第2期86-88,共3页
Cancer Research and Clinic
关键词
原发性
肝癌
骨转移
ICTP
PICP
PIINP
诊断
Primary hepatic carcinoma (PHC) Bone metastasis Carboxyterminal telepeptide of type Ⅰ collagen (ICTP) Carboxyterminal propeptide of type Ⅰ procollagen(PICP) Aminoterminal propeptide of type Ⅲ procollagen(PIINP)
