摘要
目的探讨右前额叶在区分自我和他人面孔是否是必要的，从而更加全面地理解自我意识的神经基础。方法采用1Hz重复经颅磁刺激（TMS）施加6名正常大学生被试的左或右侧背外侧前额叶，收集刺激施加前后的行为数据。结果刺激右侧背外侧前额叶的被试出现自己面孔识别的辨别力显著降低（t=4．05，P〈0．05），而刺激左侧背外侧前额叶的被试的辨别力没有显著性变化（t=1．18，P〉0．05）。此外，左、右侧背外侧前额叶刺激施加前后的反应时差异不显著（左侧TMS：t=1．43，P〉0．05；右侧TMS：t=1．80，P〉0．05），说明被试辨别力下降不是因为加快反应所致。结论1Hz重复经颅磁刺激右侧背外侧前额叶抑制了被试识别自己面孔的成绩，提示右侧背外侧前额叶参与了自己面孔识别的神经机制。
Objective To investigate the role of right prefrontal cortex in serf-otber discrimination for understanding carefully the neural system of serf-awareness. Methods Here 1Hz repetitive transcranial magnetic stimulation（rTMS） was used to create a ＂virtual lesion＂ over the right dorsal-lateral Prefrontal cortex（ rDLPFC ） in 6 subjects to test whether this region is necessary for discriminating self faces from other faces. Results The current results showed that 1 Hz rTMS to the right prefrontal cortex selectively disrupts performance on a self-other discrimination task （ t = 4.05, P 〈 0.05 ）. Applying 1 Hz rTMS to the left DLPFC had no effect （ t = 1.18, P 〉 0. 05 ）. Reaction time has no significant difference before and after rTMS （ TMS-IPFC ： t = 1.43, P 〉 0.05 ; TMS- rPFC ： t = 1.80, P 〉 0. 05）. Conclusion It appears that activity in the right DLPFC is essential to the task, thus indicating that right DLPFC is involved in self-other faces discrimination.
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2009年第1期16-18,共3页
Chinese Journal of Behavioral Medicine and Brain Science
关键词
面孔识别
前额叶
经颅磁刺激
Face recognition
Prefrontal cortex
Transcranial magnetic stimulation
