摘要
目的了解腹泻型肠易激综合征(IBS)患者肠道菌群的变化情况及微生态制剂的治疗效果。方法①随机选择腹泻型IBS组66例,对照组58例,取自然排出的新鲜粪便作活性菌培养,分析比较两组肠道微生态状况。②将IBS患者随机分为A及B两个观察组,A组和B组分别使用奥替溴铵及奥替溴铵联合双歧三联活菌胶囊进行治疗,并进行疗效分析。结果①腹泻型IBS组与正常对照组相比,双歧杆菌数量明显减少,肠杆菌数量显著增多(P<0.01);乳酸杆菌减少,酵母菌增多(P<0.05)。腹泻型IBS患者肠道B/E值小于1,对照组B/E值大于1,两组差异有显著性(P<0.01)。②A组和B组药物治疗的总有效率分别为63.6%和84.8%,两组治疗效果比较有显著差异(χ2=21.20,P<0.01)。结论腹泻型IBS与肠道菌群失调有一定的相关性,应用奥替溴铵联合双歧三联活菌胶囊治疗安全有效,值得临床摧广应用和研究。
Objective To study the changes of the intestinal microecology in patients with diarrhea-predominant irritable bowel syndrome （IBS）and the effects of microbial pharmaceuties in treating. Methods ①66 diarrhea-predominant IBS patients and 58 healthy persons（as control group）were selected randomly. Their fresh specimens will be take to perform for the culture of intestinal Flora. The microecology of the two groups will be compared and analyzed. ②66 diarrhea-predominant IBS patients were divided into the treatment group A and the treatment group B,the patients in the treatment group A were treated with Otilonium Br,and the patients in the treatment group B were treated with Otilonium and Bifid Lriple Viable. The efficacy was compared and analyzed. Results ①The number of Bifidobacterium was decreased and the number of Escherichia coli was increased obviously in the 66 diarrhea-predominant IBS patients（P〈 0.01）. Further more,the number of Cillobacterium was decreased and the number of Saccharomycete was increased also （P 〈 0.05 ）. The value of the B/E is less than 1 in the 66 diarrhea-predominant IBS patients, that value is older than 1 in the control group. The difference between the two groups was very significantly （P 〈 0.01 ）. ②The effective rate of drug treatment was 63.6% in the treatment group A and there was 84.8% in treatment group B. The difference between two groups was significantly（ X 2 = 21.20, P 〈 0.01 ）. Conclusion A certain correlation exists between diarrhea-predominant IBS and intestinal Flora imbalance. Otilonium combined with Bifid Lriple Viable can improve the clinical symptoms and signs of diarrheapredominant IBS safely. It is suggested that should be applied in clinical practice.
出处
《中国现代医生》
2009年第15期94-95,97,共3页
China Modern Doctor
关键词
肠易激综合征
肠道菌群
微生态平衡
微生态制剂
Irritable bowel syndrome
Intestinal flora
Microecology balance
Microbial pharmaceutics
