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孕妇血清甲胎蛋白筛查在监测胎儿染色体异常中的应用 被引量:1

Serum A-fetoprotein Screening in MonitoringChromosomal Abnormality among Pregnant Women from Kunming
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摘要 对2382例昆明地区正常孕妇用放射免疫测定法和酶联免疫吸附测定法,进行了母体血清甲胎蛋白(MSAFP)值测定.结果两法测定的MSAFP值无显著差异,表明检测MSAFP时,酶联免疫吸附测定法可代替放射免疫测定法.在2382例中,有1350例随访至妊娠结局,其中有35例孕妇符合采用羊膜穿刺术作胎儿染色体有否异常产前诊断指征.这35例中,MSAFP值≤05倍中位数的有16例,胎儿羊水细胞染色体检查结果发现3例染色体异常:1例是数目异常,(47,XY,+mar),1例是46,XY/46,XY,t(9∶15),1例是46,XX,13p+;MSAFP值≥20中位数的有7例,胎儿染色体检查均未发现异常,但检出经B超检查证实的2例无脑儿;MSAFP值在正常范围内的12例中,未发现胎儿染色体异常,亦未检出无脑儿.结果表明MSAFP筛查对选择有高危妊娠指征的孕妇作胎儿染色体检查有一定的作用. Maternal serum a-fetoprotein (MSAFP) value was determined by radio-immune assay and enzyme-linked immuno-sorbent assay among 2 382 normal pregnant women in Kunming. MSAFP values measured by the above two methods revealed no significant difference. The results showed that enzyme-link immuno-sorbent assay could be used to replace radio-immune assay in MSAFP test. Out of 2382 cases, 1350 were followed up till the end of pregnancy termination and 35 were given an amniocentesis to see if fetal chromosome was normal or not as a prenatal diagnosis index. In the 35 cases there were 16 cases of MSAF P<0.5 and 3 cases of chromosomal abnormality: 1 being abnormal in number (47,XY+mar), 1 being 46,XY/46,XY,t(9:15), and 1 being 46,XX,13pt; there were 7 cases of MSAF P>2.0 median, in which no abnormality was found by fetal chromosomal test but 2 cases of anencephaly were confirmed by B-ultrasonic examination; among 12 cases of normal MSAFP value neither chromosomal abnormality nor anencephaly were detected. The results showed that MSAFP screening plays a role in choosing high-risk pregnant women for chromosomal test. 
出处 《昆明医学院学报》 1998年第2期5-8,共4页 Journal of Kunming Medical College
基金 云南省应用基础研究基金
关键词 母体血清 甲胎蛋白 胎儿 染色体异常 监测 Maternal serum a-feroprotein,Radio-immuno assay,Enzyme linked immuno-sorbent assay,Fetal chromosomal abnormality
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