摘要
探讨肾小球肾炎和肾癌患者肾组织中P选择素的表达与疾病的关系。方法：采用免疫组化和原位杂交技术检测了133例肾小球肾炎、20例肾癌患者肾组织中P选择素的表达。结果：P选择素在肾小球肾炎患者的肾小管阳性表达率明显高于肾小球和肾间质；在肾小球表达，Ⅱ组（肾小球内细胞明显增生）显著高于Ⅰ组（肾小球炎症轻微）和Ⅲ组（肾小球硬化为主的晚期病变）；肾小管间质病变程度与肾小管、肾间质P选择素表达明显相关。在肾癌中，P选择素阳性表达率为55．5％，而晚期肾癌（Ⅲ、Ⅳ期）阳性表达率87．5％明显高于早期肾癌（Ⅰ、Ⅱ期）的33．3％。结论：结果提示P选择素是人类增生性肾小球肾炎早期发病的重要参与因素，并与患者肾小管间质病变程度密切相关。此外，其与肾癌浸润转移有关，并可能是一种新的肾癌转移及预后指标。
Objective: To investigate the role of P-selectin expression in human glomerulonephritis (GN)and renalcell carcinoma (RCC). Method: P-selection in renal tissues of patients with GN (n=133) and RCC (n=20) was measured by immunohistochemistry and in situ hybridization. Results: In glomerulonephritis, the up-regulated p-selectinespression on tubular epithelium was significantly higher than that in glorneruli and interstitium,and glomerular P-selectin expression was significantly up-regulated in group Ⅱ(glomerulart cells proliferation predominant)more than thatin groupⅠ(mild mflammafion in glorneruli )orⅢ (severe glomerular sclerosis ). There were strong correlations betweenthe degree of tubulo-interstitial lesions and the expression of P-selection on tubular epithelium or within the interstitium. P-selectin was positively expressed in 11 cases with RCC (55. 0% )Which was higher in Those with advanced cases(StageⅢ and Ⅳ ) than those with stageⅠ andⅡ (87. 5 %vs 33. 3%,P<0. 05). Conclusion:The results suggest that P-selectin may play an important role in the early stages of human proliferative glomerulonephritis. The up-regulation of Pselectin in tubulo-interstitium is associated with tubulointerstitial lesions,further-more,P-selectin may contribute to tumor metastasis and can be a prognostisc maker in renal. cell carcinoma.
出处
《上海医学》
CAS
CSCD
北大核心
1998年第6期320-322,共3页
Shanghai Medical Journal
基金
卫生部科研基金!94-245
上海市自然科学科研基金!97ZB14016
关键词
P选择素
肾小球肾炎
肾肿瘤
免疫组织化学
Adhesion molecule P-selectin Glomerulonephritis Renal cell carcinoma
