摘要
在过去十多年中,多羟基吲哚兹定生物碱因其结构和多样性的生物活性(抗病毒、抗肿瘤、免疫调节活性)而引起了极大的关注.其中最著名的成员是苦马豆素,一种从灰苦马豆等植物中提取出来的化合物,被证明具有治疗恶性肿瘤的作用并因此进行了大量合成研究.到目前为止文献报道的合成方法都是基于碳水化合物原料或非碳水化合物底物和不对称反应.尽管有些合成路线有效并且有实用价值,但进一步开发制备天然或非天然吲哚兹定生物碱的通用和实用方法仍然非常重要.总结了苦马毒素的合成研究进展,以便为它的规模化生产提供思路和方法.
Over the past decade, polyhydroxylated indolizidine alkaloids have received considerable attention because of their interesting structures and their diverse biological activities （e.g., antiviral, antitumor, and immunomodulating activities）. The most well-known member swainsonine, a natural product isolated from Swainsona canescens, is a potential chemotherapeutic agent for the treatment of cancer and accordingly has attracted much synthetic effort. Numerous syntheses documented to date are based on carbohydrate starting materials or asymmetric reactions using non-carbohydrate substrates. Although some syntheses are efficient and useful, further development of general and practical methods for the preparation of natural and unnatural polyhydroxylated indolizidine products is of great importance. The synthetic progresses of swainsonine are summarized in this paper.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2009年第5期690-696,共7页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(No.30070905)
陕西省重点实验室基金资助(Nos.03JS008
04JS06)资助项目
关键词
苦马豆素
合成
抗癌
swainsonine
synthesis
anticancer
