摘要
目的探讨腔内血管成形术（ＴＡ）后再狭窄形成的部分机制。方法对家兔腹主动脉粥样硬化（ＡＳ）狭窄段行ＴＡ，观察培养的ＴＡ前后及正常血管平滑肌细胞（ＶＳＭＣ）的细胞计数和１２５碘－尿嘧啶脱氧核苷参入变化。结果ＴＡ后４０ｈ的ＶＳＭＣ数值较ＡＳ－ＶＳＭＣ增加不明显，但二者较正常ＶＳＭＣ明显增加。加入血小板后，各组ＶＳＭＣ的数值明显增加，差异均具显著性。结论ＡＳ－ＶＳＭＣ及ＴＡ后ＶＳＭＣ增殖均较正常ＶＳＭＣ加快；血小板促进ＴＡ前后ＶＳＭＣ的增殖。
Objective To explore the partial mechanism of restenosis after transluminal angioplasty (TA). Methods TA was performed in celiac arteries of rabbits with atherosclerotic (AS) narrowing. The value changes of cell counting and ^(125)Ideoxyuridine interpolation of cultured vascular smooth muscle cell (VSMC) separated from arteries before and after TA and normal ones were observed. Results Values of VSMC 40 hours after TA did not increased obviously compared with those of ASVSMC, but these values were much higher than those of normal VSMC. After being stimulating with platelets, values of VSMC of all groups increased significantly. Conclusion The growth of ASVSMC and VSMC after TA were faster than normal VSMC; platelets can promote the growth of VSMC before and after TA.
出处
《安徽医科大学学报》
CAS
1998年第3期171-173,共3页
Acta Universitatis Medicinalis Anhui
关键词
血管成形术
血小板
血管
平滑肌细胞
细胞增殖
angioplasty, ballon
aorta, abdominal
blood platelets
muscle, smooth, vascular
cells, cultured
rabbits
