摘要
背景与目的孤立肺结节是肺部的常见病变,有关孤立肺结节最大层面的血流灌注模式的研究已有报道。但是这些研究只是评价了结节有限一部分的血流灌注模式,不能代表结节容积的血流灌注模式。评价整个结节的血流灌注模式应该更理想。本研究的目的是利用16层及64层螺旋CT评价孤立性肺结节容积灌注成像定量参数与大小的关系。方法65例孤立肺结节(直径≤3cm,42例恶性,12例活动性例炎性,11例良性)患者行多层螺旋CT同层动态扫描。分别计算肺结节有效层面的强化值、血流量、结节-主动脉强化值比、平均通过时间,有效层面参数的平均值作为肺结节的容积灌注成像定量参数。用线性回归分析评价孤立性肺结节CT容积灌注成像定量参数与大小的关系。结果结节容积强化值(32.15±14.55)Hu、结节-主动脉强化值比(13.20±6.18)%、血流量(29.79±19.12)mLmin-1100g-1及平均通过时间(12.95±6.53)s与大小无统计学相关(r=0.081,P=0.419;r=0.089,P=0.487;r=0.167,P=0.077;r=0.023,P=0.880。结论孤立性肺结节CT容积灌注成像定量参数与大小差异无统计学意义。
Background and objective The solitary pulmonary nodules （SPNs） is one of the most common findings on chest radiographs. The blood flow patterns of the biggest single SPNs level has been studied. This assessment may be only a limited sample of the entire region of interest （ROI） and is unrepresentative of the SPNs as a volume. Ideally, SPNs volume perfusion should be measured. The aim of this study is to evaluate the correlation between the quantifiable parameters of SPNs volume perfusion imaging derived with 16-slice spiral CT and 64-slice spiral CT and nodules size. Methods Sixty-five patients with SPNs （diameter≤3cm; 42 malignant; 12 active inflammatory; 11 benign） underwent multi-location dynamic contrast material-enhanced serial CT scanning mode with stable table were performed; The mean values of valid sections were calculated, as the quantifiable parameters of volume SPNs perfusion imaging derived with 16-slice spiral CT and 64-slice spiral CT. The correlation between the quantifiable parameters of SPNs volume perfusion imaging derived with 16-slice spiral CT and 64-slice spiral CT and nodules size were assessed by means of linear regression analysis. Results No significant correlations were found between the nodules size and each of the peak height （PHSPN） （32.15 Hu± 14.55 Hu）, ratio of peak height of the SPN to that of the aorta （SPN-to-A ratio） （13.20±6.18）%, perfusion （PSPN） （29.79 ± 19.12） mLmin^-100g^-1 and mean transit time （12.95 ± 6.53） s （r=0.081, P=0.419; r=0.089, P=0.487; r=0.167, P=0.077; r=0.023, P=0.880）. Conclusion No significant correlations were found between the quantifiable parameters of SPNs volume perfusion imaging derived with 16-slice spiral CT and 64-slice spiral CT and nodules size.
出处
《中国肺癌杂志》
CAS
2009年第5期426-429,共4页
Chinese Journal of Lung Cancer
基金
上海市重点课题(No.06DZ19503)资助~~
关键词
孤立性肺节结
灌注成像
体层摄影术
X线计算机
影像诊断
Solitary pulmonary nodule （SPN）
Perfusion imaging
Tomography
X-ray computed
Diagnostic imaging
