摘要
评价奥硝唑与甲硝唑治疗牙周炎的疗效、不良反应及成本-效果。方法将80例牙周炎患者随机分成两组,分别口服奥硝唑(治疗组)和甲硝唑(对照组),对奥硝唑与甲硝唑治疗牙周炎的疗效、不良反应进行观察并运用药物经济学成本-效果分析法进行评价。结果奥硝唑与甲硝唑治疗牙周炎的总有效率基本相同,分别为97.5%和92.5%(P>0.05);不良反应发生率分别为5%和22.5%(P<0.01);成本-效果比分别为1.49和0.89(P<0.01)。结论奥硝唑与甲硝唑均能有效治疗牙周炎。甲硝唑成本-效果比优于奥硝唑,但其不良反应发生率高于睾硝唑;从安全、依丛性考虑应优选用奥硝唑。
OBJECTIVE To estimate the curative effect, adverse reaction and cost-effectiveness of ornidazole and metronidazole in the treatment of gingivitis. METHODS 80 patients with gingivitis were randomly divided into groups for treatment with oral ornidazole （the treatment group） or oral metronidazole （the control group） respectively. Theircurative effects and the adverse reactions were observed, meanwhile both cost-effectiveness of them were evaluated by pharmacoeconomics. RE, SULTS The effective ratios were 97.5 % and 92.5 % （P 〈 0.05） for gingivitis. The ratio of the adverse reaction was 5 % for ornidazole and 22.5 % for metronidazole （P 〈 0.01）. The cost-effectiveness ratio of ornidazole was 1.49 and 0.89 for metronidazole （P 〈 0.01）. CONCLUSION Both of ornidazole and metronidazole can treat the Gingivitis effectively. The cost-effectiveness ratio of metronidazole is lower than that of ornidazole. But the adverse reaction ratio of metronidazole is higher than that of ornidazole. Considering from the safety aspect should prior to choice ornidazole.
出处
《海峡药学》
2009年第5期96-97,共2页
Strait Pharmaceutical Journal
关键词
奥硝唑
甲硝唑
牙周炎
Ornidazole
Metronidazole
Gingivitis
