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N-正丁基-1-脱氧野尻霉素的合成 被引量：4

Synthesis of N-butyl-1-deoxynojirimycin
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摘要 N-butyl-1-deoxynojirimycin(Zavesca) is an important glucosidase inhibitor,which is a kind of azasugar,which is synthesized from glucose,followed by oxidation,amination,reduction and deprotection etc.The structure of target compound is confirmed by 1H NMR. N-butyl-1-deoxynojirimycin（Zavesca） is an important glucosidase inhibitor, which is a kind of azasugar, which is synthesized from glucose, followed by oxidation, amination, reduction and deprotection etc. The structure of target compound is confirmed by 1H NMR.
作者 张硕 杨光丽 刘侠 杨劲松
机构地区 四川大学华西药学院
出处 《化学研究与应用》 CAS CSCD 北大核心 2009年第5期734-737,共4页 Chemical Research and Application
关键词 N-正丁基-1-脱氧野尻霉素 氮杂糖 合成 N-butyl-1 -deoxynojirimycin azasugar synthesis
分类号 O629.113 [理学—有机化学]
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参考文献13

  • 1Driguez H. , Thiem J. Glycoscience. Synthesis of substrate analogs and mimetics [ M ]. Berlin: Berhn Springer, 1999, 3 : 157-156. 被引量：1
  • 2Anzeveno P. B. , Creemer L. J. , Daniel J. K. , et al. A facile ,practical synthesis of 2,6-dideoxy-2,6-imino-7-O-β- D-glucopyranosyl-D-glyeem-L-gulo-heptitol [ J ]. J. Org. Chem. , 1989,54:2539-2540. 被引量：1
  • 3Fleet G. W. , Karpas A. , Raymond A. D. , et al. Inhibition of HIV replication by amino-sugar derivatives [ J ]. FEBS Lett. , 1988,237 : 128-132. 被引量：1
  • 4Woynaroska B. ,Wikiel H. ,Sharma M. ,et al. Inhibition of human ovarian carcinoma cell- and hexosaminidase-mediated degradation of extracellular matrix by sugar analogs [ J ] . Anticancer Res. ,1992,12:161-166. 被引量：1
  • 5Niwa T. ,Inoue S. ,Tsuruoka T. , et al. "Nojirimycin" as a potent inhibitor of glucosidase [ J ]. Agric. Biol. Chem. , 1970,34:966-967. 被引量：1
  • 6Inoue S. , Tsuruoka, T. , Ito T. , et al. Structure and synthesisi of nojirimycin [ J ]. Tetrahedron, 1968, 24: 2125-2126. 被引量：1
  • 7Charlotte B. , Philippe C., Olivier R. M. A stereodivergent approach to 1-deoxynojirimycin, 1-deoxygalactonojirimycin and 1-deoxymannojirimycin derivatives [ J ]. Tetrahedron Lett. ,2006,47:3081-3084. 被引量：1
  • 8Matos C. R. , Lopes R. S. C. , Lopes C. C. A formal total synthesis of deoxynojirimycin from D-glucitol [ J ]. Synthesis, 1999,4:571-573. 被引量：1
  • 9田军..氮杂糖及其衍生物的合成研究[D].河北大学,2006:
  • 10Herman S. O. , Jim van W. , Upendra K. P. A facile transformation of sugar lactones to azasugars [ J ]. Tetrahedron , 1994,50:4215-4224. 被引量：1

同被引文献54

  • 1刘斌,王长云,张洪荣,耿美玉,管华诗.海藻多糖褐藻胶生物活性及其应用研究新进展[J].中国海洋药物,2004,23(6):36-41. 被引量：41
  • 2ANZEVENO P B, CREEMER L J, DANIEL J K, et al. A facile, practical synthesis of 2,6-dideoxy-2,6- imino-7-O-fl-D-glucopyranosyl-D-glycero-L-gulo-hep- titol [ J]. J Org Chem, 1989,54( 11 ) :2539 - 2540. 被引量：1
  • 3FLEET G W, KARPAS A, RAYMOND A D, et al. Inhibition of HIV replication by amino-sugar deriva- fives [ J ]. FEBS Lett, 1988,237 ( 1/2). 128 - 132. 被引量：1
  • 4WOYNAROSKA B, WIKIEL H, SHARMA M, et al. Inhibition of human ovarian carcinoma cell-and hexosaminidase mediated degradation of extracellular matrix by sugar analogs [ J ]. Anticancer Res, 1992, 12( 1 ) : 161 - 166. 被引量：1
  • 5WENNEKES T,Van Den BERG R J B H N,DONKER W, et al. Development of adamantan-l-yl- methoxy- funcfionalized- 1-deoxynojidmycin derivatives as selective inhibitors of glucosylceramide metabolism in man[J]. J Org Chem,2007,72(4) :1088 -1097. 被引量：1
  • 6ANDERSSON U, REINKENSMEIER G, BUTTERS T D,et al. Inhibition of glycogen breakdown by imi- no sugars in vitro and in vivo E J ]. Biochem Pharma- col,2004,67 (4) :697 -705. 被引量：1
  • 7RAWLINGS A J, LOMAS H, PILLINg A W, et al. Synthesis and biological characterization of novel N- alkyl-deoxynojirimycin a-glucosidase inhibitors [ J ]- Chem Bio Chem,2009,10 ( 6 ) : 1101 - 1105. 被引量：1
  • 8SHANMUGSUNDARAM B,VASEI ,I,A A. Synthesis of new C ( 2 )-substituted gluco-configured tetrahydroin- idazopyridines and their elaluation as glucosidase inhib- itors [ J ]. Helv Chim Acta,2005 (10) :2593 - 2602. 被引量：1
  • 9YOSHIAKI A,HIVOMU M. The structure of mo- ranoline, a piperidine alkaloid from morus species [ J]. Nippon Nogei Kagaku Kaishi, 1976,50( 11 ) : 571 - 572. 被引量：1
  • 10BEAUPERE D,STASIK B,VZANET R,et al. Azi- dation s61ective du L-sorbose. Application a la synthese rapide de la 1-deoxynojirimycin[ JJ. Carbo- hydr Res, 1989,191 ( 1 ) : 163 - 166. 被引量：1

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化学研究与应用
2009年 第5期

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