摘要
目的探讨糖尿病和非糖尿病患者合并肺部感染的病原学的菌群分布与药物敏感性试验结果,为临床诊疗提供依据。方法2005～2007年住院诊断为糖尿病和非糖尿病合并肺部感染患者98例,采用痰标本进行细菌学培养及鉴定。探讨糖尿病合并肺部感染病原学分布特点和药物敏感性试验。结果在98份样品中共分离出微生物103株,其中革兰阴性菌属占48.54%,以铜绿假单胞菌及肺炎克雷伯氏菌多见;革兰阳性菌属40.78%,以葡萄球菌属为主;真菌占10.68%。药物敏感性试验显示革兰阳性菌对万古霉素保持较高的敏感率,达94%。革兰阴性菌对头孢他啶和亚胺培南的敏感率最高,2型糖尿病合并肺部感染病原菌比非糖尿病合并肺部感染病原菌更容易出现抗生素耐药。结论与非糖尿病肺部感染不同,糖尿病合并肺部感染的病原菌主要为阴性杆菌,也更易合并耐药菌感染,有必要作微生物培养和药物敏感性试验,避免不合理用药。
[Objective] To analyze the bacteria distribution and the test results of drug sensitivity of diabetes and non-diabetic combined with pulmonary infection. [Methods] 98 cases diagnosed diabetes and non-diabetic combined with pulmonary infection during 2005 to 2007, sputum samples were collected from such＇patients and cultured; pathogenic bacteria were identified. To analyse etiological distribution features and drug test sensitivity in non-diabetic combined with pulmonary infection. [Results] Of the 103 strains of pathogenic bacteria, 48.54% （50/ 98） were Gram negative bacteria, dominated by Pseudomonas aeruginosa and Klebsiella Pneumoniae; 40.78% （42/ 98） were Gram positive bacteria, dominated by staphylococcus; 10.68% （11/98） were fungi. Drug sensitivity resuhs showed that 94% Gram positive bacteria were sensitive to vancomycin, Gram negative bacteria were more sensitive to ceftazidime and imipenem. The pathogens of type 2 diabetes combined with pulmonary infection are more likely to have antibiotic resistance compared with non-diabetic patients. [Conclusion] Compared with non-diabetics, the main pathogenic bacteria of diabetes combined with pulmonary infection are Gram negative bacteria. It is more likely to combined with drug-resistant bacteria infection. To avoid antibiotics abuse on such patients, it is necessary to perform bacteria culture and drug sensitivity test.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2009年第8期1215-1217,共3页
China Journal of Modern Medicine
关键词
糖尿病
肺部感染
病原菌
药敏试验
diabetes
pulmonary infection
pathogenic bacteria
drug sensitivity test
