摘要
目的:探讨长期吸入布地奈德对支气管哮喘儿童胰岛功能及血脂的影响。方法:予68例支气管哮喘患儿吸入布地奈德治疗。于治疗前,治疗6、12、24个月取血查空腹血糖(FPG)、口服葡萄糖2h测定血糖(2hPG)、空腹血胰岛素(FINS)、血总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL)及游离脂肪酸(FFA)的水平。计算胰岛素抵抗指数(HOMA-IR)和胰岛素分泌指数(HOMA-IS)。结果:所有儿童用药前及用药6、12、24个月后其血FPG、2hPG、FINS、HOMA-IR、HOMA-IS、TC、TG、HDL-C、LDL及FFA水平均无显著性差异(均P>0.05)。结论:长期吸入布地奈德对哮喘儿童胰岛功能、胰岛素抵抗及血脂无明显影响。
Objective： To explore the changes of the function of isolated islets, insulin resistance and lipid metabolism before and after long - term inhaled budesonide in children with asthma. Methods ： 68 children with asthma were received long - term inhaled budesonide. The levels of serum FPG, 2hPG, FINS, TC, TG, HDL - C, LDL and FFA were measured, and HOMA - IR and HOMA - IS were evaluated before treatment and after treatment 6, 12, 24 months. Results： The levels of serum FPG, 2hPG, FINS, HOMA -IR, HOMA - IS, TC, TG, HDL - C, LDL and FFA in children with asthma had no significant differences before and after 6, 12, 24 month therapy （ P 〉 0.05 ） . Conclusion： The function of isolated islets, insulin resistance and lipid metabolism are not obviously affected by long - term inhaled budesonide in children with asthma.
出处
《中国妇幼保健》
CAS
北大核心
2009年第14期1926-1927,共2页
Maternal and Child Health Care of China
关键词
布地奈德
支气管哮喘
胰岛功能
血脂
Budesonide
Asthma
Function of isolated islets
Lipid metabolism
