摘要
目的:观察益气健脾、补肾活血之法对糖尿病肾病(DN)Ⅳ期的治疗效果。方法:80例DNⅣ期患者随机分为对照组和治疗组,均采用常规饮食控制、降糖、控制血压的西医治疗,治疗组加用益气活血、补肾活血的汤药。观察两组患者治疗前后空腹血糖(FBG)、餐后血糖(PBG)、糖化血红蛋白(HBA1c),尿素氮(BUN)、血清肌酐(Scr)、尿白蛋白排泄率(UAER)各项指标变化,并对临床疗效进行综合比较。结果:两组血糖、糖化血红蛋白均控制在正常范围,差异无统计学意义(P>0.05);治疗组治疗后BUN、Scr、UAER显著降低(P<0.05),明显优于对照组(P<0.05),对照组治疗后仅UAER显著降低(P<0.05);治疗组总有效率明显高于对照组(P<0.05)。结论:对脾肾两虚,气虚血瘀的DNⅣ期患者,益气健脾、补肾活血之法疗效显著,在改善肾功能、减少尿蛋白等方面可奏良效,值得临床推广。
Objective To investigate the efficacy of nourishing qi to invigorate spleen and invigorating the kidney and promoting blood circulation for diabetic nephropathy （DN）. Methods 80 patients with DN were randomized to receive routine treatment including dietary control, hypoglycemic agents, and blood pressure control （control group）, or conventional therapy plus herbal liquor with nourishing qi to invigorate spleen and invigorating the kidney and promoting blood circulation （study group）. The changes in FBG, PBG, HBAle, BUN, Scr, and UAER were determined in all patients and the efficacy of two therapies was compared. Results FBG, PBG, and HBAlc were ideally controlled in all the patients and did not differ markedly between the two groups （P 〉 0.05）. As compared with the control group, BUN, Scr, and UAER were decreased significantly in the study group （P 〈 0.05）. The efficacy in the study group was superior to that in the control group （P 〈 0.05）. Conclusions Nourishing qi to invigorate spleen and invigorating the kidney and promoting blood circulation is effective in the treatment of stage IV DN with spleen-kidney yang deficiency or qi deficiency and blood stasis.
出处
《实用医学杂志》
CAS
北大核心
2009年第9期1513-1515,共3页
The Journal of Practical Medicine
关键词
糖尿病肾病
益气健脾
补肾活血
Diabetic nephropathies
Nourishing qi to invigorate spleen
Invigorating the kidney and promoting blood circulation
