摘要
目的研究行肠汤加减干预对慢传输型便秘的结肠动力学的影响,观察其治疗慢传输型便秘的临床疗效。方法选择慢传输型便秘患者118例,分层区随机分为治疗组59例,予行肠汤加减治疗;对照组59例,予肠动力药莫沙必利治疗;疗程均为30天。观察两组治疗前后72 h结肠传输试验,疗程结束后观察两组症状积分,统计药物不良反应,并随访1年,比较复发率。结果治疗组临床症状积分显著改善,与对照组比较,差异有统计学意义(P<0.01);治疗组治愈率为76.27%,总有效率为93.22%,对照组治愈率为47.45%,总有效率为72.87%,两组比较,差异有统计学意义(P<0.01),治疗组1年复发率低于对照组(χ2=10.40,P=0.001);治疗组治疗后结肠传输功能改善优于对照组(P<0.01);两组治疗过程仅见轻度胃肠道反应,不良反应率低(治疗组5.08%;对照组8.47%),均未影响治疗。结论行肠汤能有效改善胃肠动力学,是治疗慢传输型便秘安全有效的药物。
Objective To observe the clinical efficacy of self-formulated Xingchang Decoction （XCD） in treating slow-transit constipation （S-I-C） and the dynamical parameters of colonic motility during XCD treatment. Methods One hundred and eighteen patients with STC were randomly assigned to the treatment group and the control group, 59 in each group. The treatment group was treated with XCD, and the control group was treated with mosapride, an intestinal energetic agent. The therapeutic course for both groups was 30 days. The 72-h colonic transition test was conducted and the symptom scores were observed before and after treatment; the adverse reaction rate and clinical efficacy were calculated after treatment; and the recurrence rate in one year was followed-up. Results Symptom scores were significantly improved in the treatment group after treatment, with the improvement significantly superior to that in the control group （ P 〈0.01 ）. The cure rate and the total effective rate were 76.27% and 93.22% in the treatment group respectively, while they were 47.45% and 72.87% in the control group, showing significant difference between the two groups （ P 〈0. 01 ）. Besides, the 1-year recurrence rate was significantly lower （χ2 = 10.40, P =0. 001 ） and the improvement of colonic motor function was more in the treatment group than those in the control group （P〈0.01 ）. Only low incidence （5.08% in the treatment group and 8.47% in the control group） of mild gastrointestinal reactions was shown, which caused no influence on the treatment. Conclusion XCD could effectively improve the motility of the digestive tract, and it is effective and safe for the treatment of STC.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2009年第5期403-406,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
慢传输型便秘
自拟行肠汤
结肠动力
slow-transit constipation
self-formulated Xingchang Decoction
colonic motility
