摘要
目的:探讨海昆肾喜胶囊(褐藻多糖硫酸酯)对慢性肾脏病(CKD)患者肾小管功能的影响。方法:102例CKD2、3期患者随机分为治疗组、对照组;对照组给予CKD常规治疗,治疗组在常规治疗的基础上加用海昆肾喜胶囊。观察两组治疗前及治疗后3个月、6个月的尿渗透压(UOP)、N-乙酰-β-葡萄糖苷酶(NAG)、α1-微球蛋白(α1-MG)的变化。结果:治疗组治疗后3个月NAG较治疗前明显下降(P<0.05),治疗后6个月尿渗透压较治疗前明显上升(P<0.05)、α1-MG较治疗前明显下降(P<0.05),对照组的以上指标较治疗前无明显变化(P>0.05)。结论:海昆肾喜胶囊可以减轻CKD患者肾小管损伤,改善肾小管功能。
AIM： To investigate the effect of Haikun Shenxi Capsule（Fucoidan） on tubule function in chronic kidney disease（CKD） patients. METHODS： One hundred and one patients with CKD 2-3 stage were randomly divided into two groups dora： control group were given routine therapy and therapy group were given routine therapy plus Haikunshenxi Capsule. We observed the changes of the level of UOP, NAG, α1-MG in two groups. RESULTS： The level of NAG, α1-MG significantly decreased, urine osmoticpressure significatly increased （P 〈 0.05 ） ; but there were no significantly changes in conrtol group （ P 〉 0.05 ）. CONCLUSION： Haikun Shenxi Capsule has a protective effect on tubule in CKD patients.
出处
《中成药》
CAS
CSCD
北大核心
2009年第5期682-685,共4页
Chinese Traditional Patent Medicine
关键词
海昆肾喜胶囊
慢性肾脏病
肾小管
Haikun Shenxi Capsule
chronic kidney disease
tubule
