摘要
目的探讨中国人群中血管紧张素转换酶基因（ＡＣＥ）多态性与原发性高血压之间的关系。方法应用多聚酶链（ＰＣＲ）技术检测ＡＣＥ基因１６含子中２８７ｂｐＤＮＡ片段的插入／缺失（Ｉ／Ｄ）多态性；对７０例原发性高血压患者与４５例正常对照组之间进行比较。结果在原发性高血压组Ｄ等位基因频率（０．５５）高于正常对照组０．４３，但统计学并无意义，在有高血压家族史患者中，Ｄ等位基因频率０．５８高于对照组（Ｐ＜０．０５）。结论，表明在有家族史人群中ＡＣＥ基因多态性与原发性高血压具有相关性。
Aim To investigate the association between angiotensin converting enzyme(ACE) gene polymorphism and essential hypertension among Chinese population. Methods Polymerase chain reaction(PCR) was used to examine a 287 bp insertion/deletion polymorphism in intron 16 of ACE gene. We compared the distribution of D allele frequency in 45 healthy subjects and 70 hypertensive patients. Results The D allele frequency did not differ significantly between the two groups, but it was signicantly higher(0.58) in 36 hypertensive patients with family history. Conclusion D allele gene was implicated in Chinese hypertensive population with family history.
出处
《高血压杂志》
CAS
CSCD
1998年第1期11-13,共3页
Chinese Journal of Hypertension
关键词
基因多态性
原发性
高血压
ACE
angiotensin converting enzyme
polymorphism
essential hypertension
