摘要
为探讨人尿激肽释放酶ＳＫ－８２７对心肌缺血再灌注损伤是否具有保护作用，制备了离体家兔心脏灌注模型，利用生物化学技术测定了流出液中肌红蛋白和乳酸脱氢酶含量及心肌组织丙二醛和ＡＴＰ含量。结果发现，ＳＫ－８２７对心肌缺血再灌注损伤具有明显的保护作用：它使冠状动脉流量增加（Ｐ＜０．０１）；细胞内肌红蛋白和乳酸脱氢酶漏出减少（Ｐ＜０．０１）；心肌丙二醛含量减少和心肌ＡＴＰ储备增加。这些结果提示激肽释放酶ＳＫ－８２７对治疗心肌缺血／再灌注损伤具有潜在的应用价值。
ABSTRACTAim The protective effects of human urinarykallidinogenase (SK-827 3 on myocardial ischemia/reperfusion (I/R) injury were investigated in the isolat-ed rabbit hearts.Methods Coronary effluent myoglubin (Mg) andlactate dehydrogenase (LDH ) content, myocardialmalondialdehyde (MDA ) andATP level were assayedby biochemical technique.Results in SK-827 group ,coronary flow increased ,cellular Mg and LDH leakage decreased, myocardialMDA content decreased and ATP content increased ascompared with I/R group.Conclusion SK-827 has an appliance in clinical my-ocardial I/R injury therapy.KEY WORDS SK-827; Ischemia/reperfusion in-jury ; Myoglubin ; Dehydrogenase , lactate
出处
《中国动脉硬化杂志》
CAS
CSCD
1998年第1期53-55,共3页
Chinese Journal of Arteriosclerosis
