摘要
目的：比较米氮平和西酞普兰对老年抑郁症的疗效和不良反应。方法：将60例老年抑郁症患者随机分为米氮平组和西酞普兰组,分别给予米氮平和西酞普兰治疗,疗程6周。采用汉密尔顿抑郁量表（HAMD）及不良反应量表（TESS）评定疗效和不良反应。结果：米氮平组和西酞普兰组显效率分别为83.2%和76.6%,二者疗效相仿。HAMD评分米氮平组治疗1周即显著下降,西酞普兰组治疗4周时显著下降。米氮平组嗜睡较多,而西酞普兰组常见的不良反应为恶心、口干、失眠、兴奋等。结论：米氮平是一种安全、有效的抗抑郁药物,适合用于老年抑郁症患者。
Objective：To compare the efficacy and safety of mirtazapine and citalopram in the treatment of elderly depressive patients.Methods：Sixty elderly patients with depression were randomly divided into mirtazapine group or citalopram group for 6 weeks respectively.The efficacy and side effects were evaluated by Hamilton depressive scale（HAMD） and treatment emergent sympton scale（TESS）.Results： The effective rates of mirtazapine and citalopram were 81.2 % and 76.6 % respectively,which was no significant difference between two groups.After six weeks of treatment,the scores of HAMD were significantly lower than before treatment in both groups.The scores of HAMD decreased significantly at the end of the first week in mirtazapine group,but did at the end of the fourth week in citalopram group.The incidence of somnolence was higher in mirtazapine group than in citalopram group,while the incidence of dry mouth,agrypnia,excitation or agitation was significantly higher in citalopram group than in mirtazapine group.Conclusions： Mirtazapine is a safe and effective drug in the treatment of geriatric depression.
出处
《中国民康医学》
2009年第9期968-969,972,共3页
Medical Journal of Chinese People’s Health
关键词
米氮平
西酞普兰
老年抑郁症
Mirtazapine
Citalopram
Geriatric depression
