摘要
目的:观察胞必佳联合顺铂治疗恶性胸腔积液的疗效和毒副反应。方法:47例恶性胸腔积液患者,采用一次性单腔中心静脉导管,进行胸腔穿刺置管和闭式引流术后,再给予胸腔内药物注射。治疗组26例,胞必佳400mg加顺铂80～100mg;对照组21例,顺铂80～100mg。均每周注射1次,连续3周,1月后观察两组的疗效及不良反应。结果:胞必佳加顺铂组的有效率84.6%(22/26),高于单药顺铂组66.7%(14/21),两组差异有显著性(P<0.05),且有生存质量改善。结论:胸腔置管闭式引流后注入胞必佳加顺铂是一种治疗恶性胸腔积液有效、安全的方法。
Objective：To evaluate the therapeutic effects and side effects of lyophized nocardiarubra-cell wall skeleton and cisplatin in maligant pleural effusion.Methods：Forty-seven patients with maligant pleural effusion were randomized into threatment group and control group,and treated by closed thoracic drainage with central venous catheters and intrathoracic therapy with drugs.After drainage,400mg of lyophized nocardiarubra-cell wall skeleton and 80-100mg of cisplatin were injected into pleural cavity in treatment group and only 80-100mg of cisplatin in control group weekly for 3 weeks.One month later,the efficacy and toxicities were evaluated.Results：The effective rates of treatment group and control group were 84.6%and 66.7%,respectively.The quality of life of the treatment group was higher than that in the control group.Conclusion：The closed thoracic drainage and thoracic cavity injection of lyophized nocardiarubra-cell wall skeleton and cisplatin in maligant pleural effusion is an effective and safe way.
出处
《临床肿瘤学杂志》
CAS
2009年第4期364-365,共2页
Chinese Clinical Oncology
关键词
恶性胸腔积液
胸腔闭式引流
胞必佳
顺铂
Maligant pleural effusion
Closed thoracic drainage
Lyophized nocardiarubra-cell wall skeleton
Cisplatin
