摘要
目的调查医院阴沟肠杆菌的耐药性,以指导临床治疗。方法采用VITEK-32全自动细菌鉴定仪和Kirby-Bauer法进行细菌鉴定和药物敏感试验,对近3年分离出的阴沟肠杆菌的耐药情况进行总结分析。结果临床分离阴沟肠杆菌364株,标本来源主要是痰液,对13种抗菌药物均有不同程度耐药,阴沟肠杆菌对亚胺培南耐药率最低,为3.30%,对头孢三代(除头孢哌酮/舒巴坦外)、头孢四代、喹诺酮类抗菌药物均>30.00%,对氨苄西林和头孢唑林>94.00%。结论阴沟肠杆菌对头孢菌素和喹诺酮类抗菌药物耐药严重,临床应加强检测和监测,重症患者可用亚胺培南。
OBJECTIVE To investigate antimicrobial resistance of Enterobacter cloacae in our hospital, for guiding the treatment of these infections in clinical practice. METHODS Bacterial susceptibility testing was done by Kirby- Bauer method and bacteria were identified by VITEK-32 the E. cloacae isolated from our hospital in the recent 3 Retrospective analysis of the drug resistance was done to years. RESULTS A total of 364 E. cloacae strains were isolated, which mainly isolated from sputum. They were resistant to 13 types of antibacterial agents but the resistance rate to imipenem was 3. 30%. The resistant rate to third and fourth generation cepholosporins （excepting cefoperazone/sulbactam） and quinolones was more than 30% and to ampicillin and cefazolin was more than 94.00%. CONCLUSIONS E. cloacae is severely resistant to cepholosporins and quinolones. More attention should be paid to the surveillance of such strains. Imipenem may be considered for use in critical patients.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2009年第9期1146-1148,共3页
Chinese Journal of Nosocomiology
关键词
阴沟肠杆菌
耐药性
抗菌药物
Enterobacter cloacae
Antimicrobial resistance
Antibacterial agents
