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压力支持通气模式下呼气触发灵敏度对呼吸力学指标的影响

Effects of expiratory trigger sensitivity on respiratory mechanics in chornic obstructive pulmonary disease patients during pressure support ventilation
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摘要 目的研究压力支持通气(PSV)模式下呼气触发灵敏度(ETS)对慢性阻塞性肺疾病(COPD)患者呼吸力学指标的影响,揭示ETS对通气效果的影响。方法选取2006年12月至2008年1月收入我院呼吸内科重症监护室的COPD急性加重期合并呼吸衰竭行有创机械通气患者31例,行气管插管或气管切开接伽利略金型呼吸机。病情稳定后采用PSV模式,在其他参数不变的情况下随机调整ETS%水平于5%、35%、65%,通气30~60分钟后测量呼吸力学参数及血液动力学参数。应用自身对照的方法对不同ETS%水平下呼吸力学等参数进行比较。结果随着ETS%水平增加,潮气量、吸气时间、吸呼比、呼气流速减少或下降(P〈0.01),不同ETS%水平的潮气量分别为(553.20±89.90)ml、(499.18±63.68)ml、(450.40±59.99)ml(P〈0.01),吸气时间分别为(1.18±0.34)s、(0.88±0.21)s、(0.65±0.12)s(P〈0.01),吸呼比分别为0.55±0.13、0.45±0.09、0.33±0.06(P〈0.01),呼气流速分别为(52.49±7.95)L/min、(39.64±6.85)L/min、(26.28±12.55)L/min(P〈0.01);浅快呼吸指数、呼气阻力增加或升高(P〈0.01),不同ETS%水平的浅快呼吸指数[呼吸频率(次)/潮气量(L)]分别为34.81±10.14、44.37±10.85、52.81±12.53(P〈0.01),呼气阻力分别为(15.15±3.73)cmH2O·L^-1·s^-1、(19.96±3.85)cmH2O·L^-1·s^-1、(35.38±13.75)cmH2O·L^-1·s^-1(P〈0.01),组间比较差异均有统计学意义(P〈0.01);每分钟通气量、呼气时间组间比较差异无统计学意义(P〉0.05);吸气流速、吸气阻力组间比较差异无统计学意义(P〉0.05);心率随ETS%水平有增加趋势,但组间比较差异无统计学意义(P〉0.05);经皮血氧饱和度随ETS%水平有下降趋势,但仅在ETS5%和ET Objective To evaluate the effects of expiratory trigger sensitivity(ETS) on respiratory mechanics in chronic obstructive pulmonary disease(COPD) patients during pressure support ventilation(PSV). Methods Thirtyone patients with acute exacerbation of COPD complicating respiratory failure(RF) were enrolled in the study. The patients were admitted into respiratory intensive care unit(RICU) from December, 2006 to January, 2008 for invasive mechanical ventilation, who were applied with Galileo Gold breathing machine connected by tracheal intubation or incision of trachea. After patient conditions were stable,PSV mode was used. Three levels of ETS, 5 %, 35 %,and 65 % of peak inspiratory flow(PIF) were studied in random order with the other parameters unchanged. Each ETS level lasted 30 to 60 minutes and respiratory mechanics and hemodynamics were recorded and compared. Self-control comparison study was measured. Results With ETS% level increasing, Vt,Ti, I : E, Exp Flow reduced( P 〈0.01), and the different ETS% of Vt was (553.20±89.90) ml, (499. 18±63.68) ml, (450.40±59.99) ml( P 〈0.01) ,the different ETS% of Ti was (1.18±0.34) s, (0.88±0.21) s, (0.65±0.12) s( P 〈0.01), the different ETS% of I :E was 0. 55 ± 0. 13,0.45 ± 0.09,0. 33 ±0.06 ( P 〈 0.01 ), the different ETS% of Exp flow was ( 52.49 ± 7. 95 ) L/min, (39.64 ± 6.85) L/min, (26. 28± 12. 55) L/min( P 〈0.01) ; rapid shallow breathing(RSB), Rexp increased( P 〈0.01), the different ETS% of RSB was 34. 81 ± 10.14,44. 37 ±10. 85,52.81±12.53 ( P 〈 0.01 ), the different ETS % of Rexp was (15.15±3.73) cm H2O·L^-1·s^-1,(19.96±3.85) cmH2O·L^-1·s^-1, (35. 38±13. 75) cm H2O·L^-1·s^-1 (P 〈0.01). With ETS% level increasing,there were no significant differences in VE and Te( P 〉0.05). With ETS% level increasing, Insp flow increased, Rinsp reduced, there were no significant differences in different ETS% (P0.05). With ET
出处 《临床荟萃》 CAS 2009年第9期767-770,共4页 Clinical Focus
关键词 肺疾病 慢性阻塞性 呼吸 人工 呼吸力学 pulmonary disease, chronic obsrtuctive respiration, artificial respiratory mechanics
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