摘要
目的了解不同年龄组慢性肾脏病（CKD）患者肾小球滤过率（GFR）与血清尿素氮（BUN）和血清肌酐（CREA）的相关性，及CREA和BUN在不同年龄组CKD患者肾功能的敏感性。方法测定96例CKD患者的CREA、BUN和GFR，依年龄分组进行相关关系的统计学处理，得出每组患者GFR与BUN、CREA的相关性。结果全组患者GFR与BUN、CREA均呈负相关关系，P〈0．01，且rBUN绝对值小于rCREA绝对值；分组分析提示任一组GFR与BUN、CREA全部呈负相关关系，P〈0．01，与全组患者结果一样；小于70岁的患者rBUN绝对值小于rCREA绝对值，大于等于70岁的患者其rBUN绝对值大于rCREA绝对值。结论临床工作中，利用CREA和BUN评价CKD患者的肾功能时，应考虑到年龄因素可能会导致它们敏感性的变化。小于70岁的患者，CREA的敏感性高于BUN；对于等于大于70岁的患者，BUN的敏感性可能高于CREA。
Objective The patients with chronic kidney disease （CKD）were grouped by age, to conclude the sensibility of the serum creatinine（CREA） and serum urea nitrogen（BUN） in evaluating the CKD patients＇ renal function. Methods Using statistical treatment the associativity of the date in different age stages can be Carried out, and through professional discussion the sensibility of the CREA and BUN can gained in evaluating the CKD patients＇ renal function. Then it can be a direct which use the CREA and BUN to evaluate the CKD patients＇ renal function in different age stages in clinic. Results There are negative correlation between GFR,CREA and BUN（P 〈0.01 ）. The absolute value of rBUN is smaller than the absolute value of rCREA. Through the grouping analyze, the same result to all of patients can be acquired. But in the stage of age ≥ 70 years old, the absolute value of rCREA is smaller than the absolute value of rBUN. Conclusion In clinic job, when the CKD patients＇ renal function is evaluated by CREA and BUN, it should be allowed for that the age may influence the sensibility of CREA and BUN,in the stages of age ≤70 years old,the sensibility of CREA may be better than the BUN,and in the stages of age ≥70 years old,the sensibility of BUN may be better than the CREA.
出处
《中国临床实用医学》
2009年第5期36-38,共3页
China Clinical Practical Medicine
