摘要
目的研究三阴性乳腺癌(TNBC)的临床病理特征,总结诊治经验。方法回顾性分析第二军医大学附属长海医院甲乳外科2005年6月—2008年8月收治的81例TNBC患者临床资料,总结其临床病理特征和随访结果。结果TNBC占同期乳腺癌总数的16.5%(81/492)。本组病例好发于40～59岁(44.5%)女性,平均肿瘤直径为(3.2±2.3)cm。随访2～37个月,中位时间为21个月,8例患者出现复发转移,死亡5例,其中非肿瘤原因死亡1例,远处转移死亡4例(1例术后10个月发现肺、胸椎转移;1例术后15个月发现全身淋巴结转移伴腰椎转移;其他2例均为肺转移,分别出现在术后8和24个月)。临床分期主要为Ⅱ期(56.8%),组织学类型以浸润性导管癌为主(81.5%)。化学治疗是TNBC的主要治疗手段。结论TNBC是一种高危乳腺癌,好发于40～59岁女性,肿瘤直径较大,复发风险较高,易发生远处转移。化学治疗是其主要治疗手段,应慎重选择化疗药物以提高临床缓解率,改善预后。
Objective To describe the clinicopathological features of women with triple negative breast cancer （TNBC）, and to summarize our experience in diagnosis and treatment of the disorder. Methods We retrospectively analyzed the clinical data of a cohort of 492 patients with ＂FNBC, who were treated during June 2005 and August 2008 in Changhai Hospital. The clinical features and follow up outcomes were summarized. TNBC were defined as estrogen receptor negative, progesterone receptor negative, and human epidermal growth factor receptor 2 negative. Results Eighty-one patients accounted for 16.5% of the total 492 patients who had breast cancer during the period. The disease was likely to occur in patients aged 40- 59 years old （44.5%）, with the mean diameter of （3.2±2.3） cm. The follow up period was 2- 37 months, with a median follow-up time of 21 months. Recurrence and metastasis occurred in 8 patients and 5 patients died, one due to non-tumor reason, 4 due to distant metastasis （one had lung and thoracic metastasis 10 months after operation, one had global lymphatic and lumbar metastasis 15 months after operation, the other 2 had lung metastasis 8 and 24 months after operation）. The patients were mainly identified as stage Ⅱ in the clinic. The most common histological types were mianly invasive ductal carcinomas （81.5%）. Chemotherapy was the main therapy of patients with TNBC. Conclusion TNBC is highly dangerous and has a predilection to occur in patients aged 40- 59 years old. The tumor has a larger diameter and high incidence of recurrence and metastasis. Chemotherapy is the main treatment and the chemo agents should be chosen with caution.
出处
《上海医学》
CAS
CSCD
北大核心
2009年第4期322-324,I0002,共4页
Shanghai Medical Journal
关键词
乳腺癌
三阴性
临床病理特征
Breast cancer
Triple negative
Clinicopathological features
