摘要
目的探讨人颈动脉粥样硬化斑块内幽门螺杆菌-细胞毒素相关蛋白A(Hp-CagA)-IgG抗体的表达水平与颈动脉粥样硬化性脑梗死之间的关系。方法选择24例因颈动脉粥样硬化狭窄行颈动脉内膜切除术且合并Hp-CagA阳性菌株感染的患者,分为有缺血性脑卒中事件组(16例)和无缺血性脑卒中事件组(8例),采用酶联免疫吸附试验检测颈动脉粥样硬化斑块内Hp-CagA-IgG抗体浓度。结果有缺血性脑卒中事件组的颈动脉粥样硬化斑块内Hp-CagA-IgG抗体浓度显著高于无缺血性脑卒中事件组(P<0.05)。结论颈动脉粥样硬化斑块内Hp-CagA-IgG抗体表达的增高可能通过影响斑块的稳定性,导致颈动脉粥样硬化性脑梗死的发生。
Objective To explore the association between Helicobocter pylori-cytotoxin-associated protein A-antibody IgG （Hp-OagA-IgG） in carotid atherosclerotic plaque and carotid atherosclerotic cerebral infarction. Methods A total of 24 patients with carotid atherosclerotic sclerostenosis undergoing carotid endarterectomy complicated with Hp-OagA positive strain infection were selected in this study. The patients were divided into two groups： with ischemic stroke incident （n=16） and without ischemic stroke incident （n = 8）. The presence of Hp-OagA-IgG antibody in the carotid atherosclerotic plaques was performed by enzyme linked immunosorbent assay （ELISA）. Results The level of Hp-OagA-IgG antibody in the carotid atherosclerotic plaque in group with ischemic stroke incident was significantly higher than that in group without ischemic stroke incident （P〈0.05）. Conclusion High expression of Hp-CagA-IgG antibody in carotid atherosclerotic plaque may affect carotid atherosclerotic plaque stability, which may subsequently cause carotid atherosclerotic cerebral infarction.
出处
《上海医学》
CAS
CSCD
北大核心
2009年第4期296-298,共3页
Shanghai Medical Journal
基金
上海市浦江人才培养计划(08PJ1400300)
留学回国人员科研启动基金(2008890)资助项目
