摘要
Ghrelin是生长激素促分泌素受体的内源性配体，主要在胃部产生，也广泛分布于其他组织，具有多种生物学效应。近年来研究发现ghrelin可抑制多种细胞的凋亡，包括神经细胞、心肌细胞、骨细胞、内皮细胞、胰岛细胞及小肠上皮细胞等，其中可能涉及到腺苷酸环化酶／cAMP／蛋白激酶A、磷脂酰肌醇3激酶／蛋白激酶B、细胞外信号调节激酶1／2等信号转导途径。这方面的研究有一定的临床价值，将来有望应用于疾病的诊断和治疗，本文就ghrelin的抗细胞凋亡作用及其机制作一综述。
Ghrelin, the endogenous ligand of the growth hormone secretagogue receptor, is secreted mainly by gastric tissue but also found in many other tissues. Recent researches found that ghrelin inhibits apoptosis in a few types of cells, such as neuronal cells, pancreatic beta cells, bone cells, intestinal epithelial cells ,cardiomyocytes, endothelial cells and so on, invoving adenylyl eyclase/cAMP/protein kinase A （AC/ cAMP/PKA）, phosphatidyl inositol 3-kinase/protein kinase B（PI3K/Akt） and extraeellular signal-regulated kinase（ERK） 1/2 signaling pathways. The research has clinical value and may be applied to diagnosing and curing diseases in the future. Researches about anti-apoptosis effect of ghrelin in recent years are reviewed in this paper.
出处
《国际内分泌代谢杂志》
2009年第B04期38-41,共4页
International Journal of Endocrinology and Metabolism
