摘要
目的:探讨STAT3蛋白在肝细胞癌(HCC)组织中的表达及在HCC发生、发展中的意义。方法:应用免疫组化方法检测56例HCC组织及其癌周肝组织,11例肝硬化组织和11例正常肝组织中STAT3蛋白的表达;检测VEGFR2、EGFR分别在27、42例HCC组织中的表达情况。结果:STAT3蛋白在HCC组织的阳性、强阳性表达分别为23和9例,其阳性表达率在HCC组织中显著高于癌周肝组织,癌周肝组织显著高于肝硬化组织,肝硬化组织显著高于正常肝组织,P<0.01;STAT3蛋白在HCC组织中的表达与VEGFR2和EGFR的表达无显著相关性,P>0.05。结论:STAT3蛋白表达与HCC的发生、发展密切相关。
OBJECTIVE： To investigate the expression of signal transducer and activator of transcription 3（STAT3） protein in hepatocellular carcinoma（HCC） tissues and its significance in occurrence and development of HCC. METHODS： The expression of STAT3 protein was examined with immunohistochemical technique in the specimens from 56 HCC tissues and their para-carcinoma tissues, 11 hepatic cirrhosis tissues and 11 normal liver tissues, and the expressions of VEGFR2 and EGFR were examind in 27 and 42 HCC tissues, respectively. RESULTS： The positive and strongly positive expressions of STAT3 protein in HCC tissues were in 23 and 9 cases respectively, the positive rate of STAT3 expression was significantly higher in HCC tissues than in the para-carcinoma tissues, its expression in para-carcinoma tissues was higher than that in hepatic cirrhosis tissues, and its expression in hepatic cirrhosis tissues was significantly higher than that in normal liver tissues, P〈0.01. The expression of STAT3 was correlated with the expression of AFP in HCC tissues, P〉0.05. There was no significant correlation between the expression of STAT3 protein and the expressions of VEGFR2 and EGFR in HCC tissues. CONCLUSIONS： The expression of STAT3 is closely correlated with the occurrence and development of HCC.
出处
《中华肿瘤防治杂志》
CAS
2009年第7期523-525,552,共4页
Chinese Journal of Cancer Prevention and Treatment
