摘要
2型糖尿病是一种异质性疾病，主要的遗传因素是β细胞功能受损。功能改变表现为一系列的组织学、病理生理学变化。2型糖尿病患者胰岛素分泌缺陷可能与胰岛素缺乏和β细胞分泌缺陷这两点有关。同时，β细胞量的减少和β细胞功能受损在糖尿病的持续进展中发挥了至关重要的作用。
Type 2 diabetes is a heterogeneous disorder caused by concomitant impairment of β-cell dysfunction, the hallmark of which is a series of abnormalities of histology and pathophysiology. The impairment of insulin secretion of type 2 diabetes is related to insulin deficiency and abnormal β-cell secretion. The progressive deterioration in β-cell function and mass in type 2 diabetes are the driving forces for the disease progression.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2009年第2期I0014-I0016,共3页
Chinese Journal of Endocrinology and Metabolism
关键词
糖尿病
2型
Β细胞
Diabetes mellitus, type 2
β-cell
