摘要
目的通过诊断试验Meta分析,综合评价IHC和MSI对HNPCC的诊断效果。方法通过检索Pubmed、Medline、Ovid等数据库,获得有关IHC或MSI筛查HNPCC的文献,提取相关数据;采用SAS8.02进行诊断试验Meta分析。结果Meta分析稳健法结果显示IHC法的综合灵敏度为0.826,诊断优势比为22.537;MSI法的综合灵敏度为0.852,诊断优势比为33.115。结论两种HNPCC筛查方法效果较好,但两方法诊断效果无统计学意义,均对HNPCC具有理想的诊断价值。
Objective Through the meta-analysis of diagnostic test, comprehensively evaluate the diagnostic test of IHC and MSI to screen HNPCC. Methods We searched PUBMED, MEDLINE, OVID for English language studies in which HNPCC was screened by IHC or MSI. Analysis was undertaken using SAS Software, version 8.02. Results Robust method of meta analysis indicated that the TPR^ ＊ of IHC was 0. 826 and diagnostic OR was 22. 537. MIS screening method were 0. 852 and 33. 115 respectively. Conclusion Both IHC and MSI can be used in diagnosis of HNPCC for the accuracy of them are moderate, but there was no significance between them.
出处
《中国卫生统计》
CSCD
北大核心
2009年第2期143-146,共4页
Chinese Journal of Health Statistics
关键词
遗传性非息肉病性结直肠癌
META分析
错配修复
免疫组织化学
微卫星不稳定
Hereditary nonpolyposis colorectal cancer （HNPCC）
Meata analysis
Mismatch repair（MMR）
Immunohistochemistry（IHC）
Microsatellite instability（MSI）
