摘要
目的探讨氨甲蝶呤（MTX）对巧克力囊肿治疗的可行性及临床效果。方法本研究选择确诊为巧克力囊肿并符合介入治疗条件、不愿手术或术后复发不愿再次手术者，或曾经药物治疗效果差要求行穿刺治疗的60例患者，随机分成Ⅰ组与Ⅱ组，每组30例。月经干净3-5d时，由专人经阴道超声引导下穿刺入囊肿中心，温生理盐水冲洗囊腔后，Ⅰ组注入MTX 50mg＋生理盐水10ml，Ⅱ组注入MTX 75mg＋生理盐水10ml。术后随访6个月，观察两组囊肿大小、临床症状、生育情况等。结果本研究观察到，应用不同剂量MTX加服孕三烯酮治疗巧克力囊肿有较高治愈率，复发率低，且治疗效果呈剂量依赖性。结论超声引导下氨甲蝶呤能够有效治疗巧克力囊肿，降低复发率及不孕率。
Objective To Investigate the feasibility and clinical effect of MTX on ovarian endometriosis. Methods This study choosed 60 patients diagnosed as chocolate ovarian cysts and fit to the interventional therapy. The patients had completed data not to surgery or who do not want to re - operation or who had drug treatment with poor effect to require puncture treatment. They were randomly divided into two groups with 30 cases. 3 to 5 days after cleaning of menstruation, the professional staff punctured into the cyst with ultrasound - guided needle through the vaginal. After washing cysts with warm saline, 30 cases were injected with MTX 50 mg and NS 10 ml. Another 30 cases were injected with MTX 75 mg and NS 10 ml. Following up visit at 3 month, 6 month after operation. To observe the cyst size, clinical symptoms and fertility between the two groups after thrapy. Results We observed that the application of different doses of MTX plus gestrinone to treat ovarian chocolate cysts have a higher cure rate, low relapse rate. The incidence of pregnant patients reduced. The treatment effect is dose - dependent manner. Condusion Ultrasound - guided treatment with MTX to ovarian chocolate cysts is effect.
出处
《中国医学创新》
CAS
2009年第13期1-3,共3页
Medical Innovation of China
基金
2008年膝州市科技发展计划第一批（NO：2008071）
