摘要
目的:探讨热休克蛋白(HSP)70和DNA修复酶O6-甲基鸟嘌呤-DNA甲基转移酶(O6-methygua-nine-DNA methytransferase,MGMT)在大肠癌中的表达及临床意义。方法:采用免疫组织化学SABC法检测61例大肠癌组织中MGMT与HSP70的表达情况。结果:MGMT与HSP70在大肠癌中表达的阳性率分别为50.82%和62.30%。其中,二者都与性别及分化程度相关性不明显(P>0.05);而与年龄和浸润深度有相关性(P<0.05),且二者呈正相关(P<0.05;r=0.32)。结论:MGMT与HSP70在大肠癌的发生发展中可能起重要作用,检测它们对大肠癌的防治有重要的临床指导意义。
Objective：To detect the expression of MGMT and HSP70 and their relationship on tumorigenesis and progression. Methods：The expression of MGMT and HSP70 in cancer tissue of 61 cases which were examined by SABC immunohistoehemistry. Results：The positive rate of MGMT and HSP70 in center tissue were 50.82% and 62.30%. The expression of MGMT and HSP70 were not associated with the patients＇ sex or divide degree （ P 〉 0.05 ） ; but they were related with the age of patients and lymphnode metastases and the invasion of cancer cell （ P 〈 0.05 ）, also, there were relationship between them （ P 〈 0.05, r = 0. 32）. Conclusion： Analysing the expression of MGMT and HSP70 in colorectal cancer have the clinical guidance functions
出处
《现代肿瘤医学》
CAS
2009年第5期886-887,共2页
Journal of Modern Oncology
基金
河北省科技厅攻关项目(编号:3276117)
