摘要
[目的]探讨影响肺癌脑转移预后的相关因素,为肺癌临床治疗提供参考依据。[方法]回顾性分析本院2006～2007年84例肺癌脑转移患者的临床资料,放疗采用6MV-X全脑姑息放疗,剂量30Gy/2周。生存分析采用Kaplan-Meier法并进行Log-Rank检验,通过比例风险模型(Cox模型)进行多因素分析。[结果]单因素分析显示患者的行为状态(PS评分)、病理类型、脑转移时间和近期疗效等对生存期有影响(P<0.05),同步脑转移组和后发脑转移组的1年生存率分别为75.6%、39.5%。多因素分析显示脑转移时间和近期疗效与预后有关(P<0.05)。[结论]PS评分、脑转移时间和近期疗效是肺癌脑转移独立的预后因素。后发脑转移及近期疗效呈CR、PR者是肺癌脑转移良好的预后因素,这些患者的生存期较长,是潜在的治疗获益人群。
[ Purpose ] To investigate the prognostic factors in lung cancer patients with brain metastases, to provide reference for clinical treatment for lung cancer. [Methods] The clinical data of 84 cases with lung cancer with brain metastasis from 2006 to 2007 were reviewed retrospectively.Radiotherapy using 6MV-X palliative whole brain radiation therapy, DT30Gy/2w. Survival was analyzed by Kaplan-Meier method and Log-Rank test. The multivariate analysis was performed with Cox＇s proportion risk model. [ Results ] The uni- variate analysis showed that patients＇ performance status（PS score）, pathological type, the time of brain metastasis and short-term response correlated to survival （P〈0.05）. One-year survival rate for synchronous brain metastasis and after brain metastasis were 75.6% and 39.5% respectively. The multivariate analysis indicated that time of brain metastasis, and short-term response were closely related to prognosis （P〈0.05）. [Conclusion] After brain metastasis and short-term CR＋PR are the independent prognostic factors in lung cancer with brain metastasis.
出处
《肿瘤学杂志》
CAS
2009年第4期320-323,共4页
Journal of Chinese Oncology
关键词
肺肿瘤
脑转移
放射治疗
生存分析
lung neoplasm
brain metastasis
radiation therapy
survival
