摘要
目的研制四乙酰基葛根素双层片并考察其体外释药特征。方法干法制粒压制双层片,HPLC测定四乙酰基葛根素的释放度。结果考察得到四乙酰基葛根素双层缓释片处方合理,其释药曲线用Higuchi方程拟合,可维持12 h持续释放。结论四乙酰基葛根素双层缓释片的研制达到设计要求。
Objective To study the tetra-acetylated puerarin double-layer tablets and evaluate its release characteristics. Methods The double-layer tablets were prepared by dry granulation and the dissolution of tetra-acetylated puerar in was determined by HPLC. Results The formulation was reasonable, and the curve of cumulative release of tetra acetylated puerarin double-layer tablets accorded with Higuchi equation. The tetra-acetylated puerarin sustained for 12 hours. Conclusion The prepared tetra-acetylated puerarin double-layer tablets achieve the design goal.
出处
《中南药学》
CAS
2009年第4期246-249,共4页
Central South Pharmacy
基金
深港创新圈专项资助计划-应用研发专题(SG200710190095A)
关键词
四乙酰基葛根素
双层片
HPLC
体外释药
tetra-acetylated puerarin
double-layer tablets
HPLC
in vitro release
