摘要
为探索肝移植后早期深部真菌感染的早期诊断和治疗措施,收集了重庆医科大学附属第一医院重庆市器官移植中心2001-10/2008-10的72例肝移植患者移植后并发早期深部真菌感染16例患者的临床资料,分别对其易感因素、病原学特点、诊断方法、治疗方案及预防措施进行回顾性病例分析。16例肝移植患者发生早期深部真菌感染23例次,死亡4例,感染发生率22.2%(16/72),死亡率25.0%(4/16)。肺部感染15例次,肠道感染6例次,胆道感染1例次,颅内感染1例次。白色念珠菌感染占65.22%,非白色念珠菌感染占17.39%,曲霉菌感染占13.04%,隐球菌感染占4.35%。发病时间为移植后5～26d。可见早期深部真菌感染是影响肝移植患者后生存率的重要原因之一。有效预防、早期诊断和积极治疗是提高深部真菌感染治愈率的关键。
To investigate the early diagnosis and therapeutic measures of early deep fungal infection after liver transplantation, clinical data of 16 of 72 patients undergoing liver transplantation with early deep fungal infection from were retrospectively analyzed from October 2001 to October 2008 in Chongqing Organ Transplantation Center, First Affiliated Hospital of Chongqing Medical University. The predisposing factors, etiological characteristics, diagnostic methods, treatment protocols and preventive measures were analyzed. Twenty-three case-times of deep fungal infection were diagnosed in 16 cases, and 4 died. Infection rate was 22.22% （16/72）, and mortality was 25.0% （4/16）. Fifteen case-times of pulmonary infection, 6 case-times of intestinal infection, 1 case-times of infection of biliary tract and 1 case-times of intracranial infection occurred, of which Candida albicans accounted for 65.22%, non Candida albicans for 17.39%, Aspergillus for 13.04%, and Cryptococcus for 4.35%. Onset time was 5 to 26 days after liver transplantation. The results show that early deep tungal infection is one of important causes influencing survival rate after liver transplantation. Effective prevention, early diagnosis and active treatment are key points of increasing recovery rate of deep fungal infection.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第18期3511-3514,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
