摘要
目前肝移植取得了迅速的发展,但也面临着一些问题,主要是如何诱导稳定而持久的免疫耐受,以及如何确定和维护已形成的免疫耐受。恰当地选择药物组合,维持适度的免疫抑制状态,减少药物的副作用及相关并发症,切实提高移植患者的生活质量和生存率。文章研究了肝移植后免疫耐受的产生机制,介绍了常见的免疫抑制剂及作用机制,探讨了免疫调节治疗方案及个体化治疗,并展望了免疫调节药物治疗关注的问题。
So far, liver transplantation has made a rapid development, but it also faces some problems. The main problems are how to induce stable and persistent immune tolerance, and how to determine and maintain formed immune tolerance. Selecting the proper drug combination, maintaining the moderate immunosuppressive condition, and decreasing the side reactions and complications induced by drugs can practically improve the life qualities and survival rates of the transplant patients. The article studies the production mechanism of immune tolerance, introduces some common immunosuppressants and their effect mechanisms, investigates treatment protocols of immune regulation and individual treatment, and prospects concerned problems of drug treatment of immune regulation.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2009年第18期3495-3498,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
