摘要
目的观察2型糖尿病病人口服阿司匹林后高敏C反应蛋白(hs-CRP)、白细胞介素6(IL-6)及肿瘤坏死因子α(TNF-α)血清浓度的变化。方法82例2型糖尿病病人,分成2组。试验组与对照组病人均给予常规降糖和降压治疗,试验组病人加服阿司匹林100mg·d-1,观察1年。分别于观察开始和1年后测定空腹血糖(FBG)、胰岛素(FINS)、糖化血红蛋白(HbA1c)和血清hs-CRP、IL-6、TNF-α等水平。结果治疗后,2组病人FBG和HbA1c均明显下降,与治疗前相比差异非常显著(P<0.01),其中试验组FBG下降幅度大于对照组(P<0.01)。试验组FINS和胰岛素抵抗指数也下降,而对照组无显著变化,2组有非常显著差异(P<0.01)。试验组hs-CRP、IL-6和TNF-α分别下降(1.2±s0.4)mg·L-1、(6±4)ng·L-1和(6±7)ng·L-1,下降幅度明显大于对照组(0.13±0.05)mg·L-1、(0.02±0.13)ng·L-1和(1.3±1.0)ng·L-1,差异非常显著(P<0.01)。试验组出现恶心、上腹部不适2例,停药1例。结论阿司匹林能降低2型糖尿病病人的炎症因子水平,抗炎治疗可作为预防和治疗2型糖尿病的一种方法。
AIM To observe the changes of serum high-sensitivity C-reactive protein （hs-CRP）, interleukin 6 （IL-6）, and tumor necrosis factor ot （TNF-α） level in patients with type 2 diabetes mellitus （T2DM） after orally taking aspirin. METHODS Eighty-two T2DM patients were divided into trial group and control group. They were treated by normalization of blood glucose and decrease of blood pressure for one year. Aspirin 100 mg·d^-1 was given additionally to patients in the trial group during the same period. The levels of fasting blood glucose （FBG）, fasting insulin （FINS）, hemoglobin Alc （HbAlc）, hs-CRP, IL-6 and TNF-α of T2DM patients in the treated group and the control group were measured before and one year after the treatment. RESULTS By the end of one year, the levels of FBG and HbAlc decreased in both groups with significant difference than before （P 〈 0.01 ）, and FBG in the trial group decreased more obviously than that in the control group （P 〈 0.01 ）. The levels of FINS and insulin resistant index also decreased in the trial group, while those in the control group did not change significantly, showing significant difference between the two groups （P 〈0.01）. The serum levels of hs-CRP, IL-6 and TNF-α decreased （1.2 ± s 0.4） mg·L^-1, （6 ± 4） ng·L^-1 and （6± 7） ng·L^-1 in the trial group versus （0.13 ± 0.05） mg·L^-1, （0.02 ± 0.13） ng·L^-1 and （1.3 ± 1.0） ng·L^-1 decreased in the control group respectively, showing significant more decrease of those in the trial group （P 〈 0.01 ）. The adverse reactions after taking aspirin were nausea and upper abdominal upset for just two patients with stop aspirin intake in one. CONCLUSION T2DM patients treated by aspirin could decrease the inflammatory factors and thus the anti-inflammation is a choice for preventing and treating patients with T2DM.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2009年第4期297-300,共4页
Chinese Journal of New Drugs and Clinical Remedies
