摘要
目的研究十二指肠溃疡患者使用三联疗法治疗幽门螺杆菌（Hp）感染的根除率，评估患者依从性、年龄、性别对于此类人群根除Hp治疗的影响。方法新发十二指肠溃疡并明确有Hp感染的1038例患者均接受三联（洛赛克或耐信联合克拉霉素与阿莫西林）7d疗法行根除Hp治疗，之后予以耐信或洛赛克治疗35d。系统治疗完成后6—8周复查胃镜。结果十二指肠溃疡病患者Hp根除率为77．0％。40岁以下人群的治疗依从性较差，40岁以下与40岁以上患者的Hp根除率有统计学差异（P〈0．05）。不同性别十二指肠溃疡患者的Hp根除率无统计学差异（P〉0．05）。结论三联7d疗法对十二指肠溃疡病患者Hp的根除率较低，患者对治疗的依从性、年龄是影响十二指肠溃疡患者Hp根除率的重要因素。
Objeelive To observe the eradication rate of H. pylori in a duodenal ulcer population under this treatment. The influence of compliance to therapy, age, and gender was also evaluated. Methods A series of 1 038 consecutive patients, drawn from new diagnosed to have duodenal ulcer disease by upper endoscopy and H. pylori infection by histological examination. All patients underwent standard triple therapy for 7 days （ Losec or Nexium, Clarithromycin, and Amoxicillin）. Then all patients were treatment with Losec or Nexium for a period of 35 days. All patients were performed upper endoscopy 6-8 weeks after completion of all the treatment. Results The total H. pylori eradication rate of duodenal ulcer patients was 77.0%. H. pylori eradication rate of duodenal ulcer patients was significant lowest in 〈 40 years old, higher in 40-59 years old and in 60 years old （P 〈 0.05 ）. The gender did not affect H. pylori eradication rate in the three groups （ P 〉 0.05 ）. Conclusions The 7-days of triple therapy with Amoxicillin, Clarithromycin, and a proton pump inhibitor had a poor eradication rate of H. pylori infection, even though, the compliance to therapy, and age seem to affect the eradication rate of H. pylori infection of duodenal ulcer.
出处
《山东医药》
CAS
北大核心
2009年第16期6-8,共3页
Shandong Medical Journal
