摘要
阻塞性睡眠呼吸暂停综合征（OSAHS）是以反复上呼吸道阻塞造成夜间呼吸暂停和夜间低氧为特征的一种睡眠呼吸疾患。夜间低氧可引起血清炎性因子水平升高,血清炎性因子又可通过多种机制导致夜间睡眠结构紊乱而加重OSAHS。炎性因子导致OSAHS患者睡眠结构紊乱,对OSAHS的发病机制研究以及预防与其密切相关的心脑血管并发症至关重要。
Obstructive sleep apnea-hypopnea syndrome （OSAHS） is characterized by recurrent collapse of the pharyngeal airway during sleep, resulting in substantially reduced （hypopnea） or complete cessation （apnca） of airflow despite ongoing breathing efforts. These disruptions to breathing lead to hypoxemia during nighttime which significantly increase inflammatory factors. The high level of serum inflammatory factors aggravate OSAHS by impacting sleep fragmentation. Inflammatory factors cause disordered sleep architecture in patients with OSAHS. It is essential to study the pathogenesis of OSAHS,as well as to prevent cardiovascular and cerehrovascular complication which closely related to OSAHS.
出处
《医学综述》
2009年第9期1301-1303,共3页
Medical Recapitulate
关键词
阻塞性睡眠呼吸暂停综合征
炎性因子
睡眠结构紊乱
Obstructive sleep apnea-hypopnea syndrome
Inflammatory factor
Sleep fragmentation
