摘要
结合并发约束理论提出了并发Analog-Cell模型框架;基于扩展的并发约束理论,提出了并发Analog-Cell中定量的随机控制机制以及模拟细胞中RNA聚合酶介导转录起始过程的算法模型,可有效地避免系统中随机错误的发生并提高运行效率;最后,提出了并发Analog-Cell模型中DNA转录过程的模拟算法.
Analog-Cell represents gene expression at the molecule level. It provides abundant image information. We carded out investigations on concurrent semantic analysis of Analog-Cell in this paper. We introduced concurrent constraint theory into Analog-Cell and presented a framework of concm＇rent electronic cell model. We designed a quantitative stochastic control mechanism, which was based on the study of stochastic concurrent conswaint programming. It is capable of avoiding the random system mistakes and improving the performance efficiency of Analog-Cell. Based on non-deterministic temporal concurrent constraint theory, we presented an algorithm model to simulate the initiation of transcription. Last but not least, we proposed an algorithm to simulate whole transcription process.
出处
《电子学报》
EI
CAS
CSCD
北大核心
2009年第4期786-791,共6页
Acta Electronica Sinica
基金
国家自然科学基金重大项目基金(No.60496320
60496321)
国家自然科学基金(No.60773097
60873148)
新世纪优秀人才支持计划项目基金
吉林省科技发展计划项目基金(No.20060532
20080107)
欧盟项目基金TH/Asia Link/010(No.111084)
吉林省杰出青年基金(No.20080107
20080617)
关键词
电子细胞
并发约束程序
生物建模
electronic cell
concurrent constraint programming
biological modeling
