摘要
目的调查银屑病伴发代谢综合征患者的临床特点。方法对202例银屑病患者进行问卷调查、体格检查和实验室检查,指标包括身高、体重、腰围、空腹血糖、甘油三酯、高密度脂蛋白胆固醇和血压。代谢综合征诊断标准采用2005年国际糖尿病联盟(IDF)制定的标准。比较伴发代谢综合征的银屑病患者(MS组)与不伴发代谢综合征的银屑病患者(非MS组)的性别、年龄、发病年龄、病程、病情严重程度、文化程度、家族遗传史、生化指标及生活方式。结果202例银屑病患者伴发代谢综合征者45例,占22.27%;MS组患者腰围、空腹血糖、甘油三酯、血压均较非MS组高,高密度脂蛋白胆固醇较非MS组患者低,差异均具有统计学意义(P<0.01);MS组患者较非MS组患者年龄大,发病年龄晚,病程长,病情重,差异有统计学意义(P<0.05);生活方式调查显示MS组吸烟、饮酒患者明显多于非MS组(P<0.05)。结论银屑病患者代谢综合征的发生率较高,可能与吸烟、饮酒等不良生活方式有关。
Objective To evaluate the prevalence of metabolic syndrome （MS） in patients with psoriasis, and explore the clinical features of the patients with metabolic syndrome-associated psoriasis. Methods Two hundred and two patients with psoriasis were investigated by face-to-face questionnaire, physical and laboratory examinations. Information included age, sex, the age of onset, duration of the disease, disease severity, family history, education level, waistline, fasting plasma glucose （FPG）, triglyceride （TC）, high-density lipoprotein cholesterol （HDL-C） and blood pressure （BP）. The diagnosis of MS was established according to the criteria of International Diabetes Federation （IDF）. Results ① Of 202 patients with psoriasis, 45 suffered from metabolic syndrome, accounting for 22. 27%.② The patients with metabolic syndrome-associated psoriasis always had significantly higher average age and the age of onset, longer disease history and severer symptoms than those psoriasis patients without metabolic syndrome （P〈0. 05）, while no significant difference was found between the two groups in sex, family history and education level （P〉0. 05）. ③ The patients with metabolic syndrome-associated psoriasis had significantly longer waistline, fasting plasma glucose, triglyceride, blood pressure and lower high-density lipoprotein cholesterol than the psoriasis patients without metabolic syndrome （P〈0.01）.④ More psoriasis patients with metabolic syndrome were smokers and indulging in drinking than those psoriasis patients without metabolic syndrome （P〈0. 05）, while no evident difference existed between the two groups in exercises and sleep （P〉0.05）. Conclusion Metabolic syndrome is highly prevalent among the patients with psoriasis, which might be associated with smoking and drinking.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2009年第5期622-624,共3页
Medical Journal of Chinese People's Liberation Army
关键词
银屑病
代谢综合征
临床特点
psoriasis
metabolic syndrome
clinical characteristics
