摘要
肾间质纤维化几乎是所有肾脏疾病进展到终未期肾功能衰竭的共同病理途径,近年研究表明,肾小管上皮细胞向间充质细胞转分化(EMT)是肾间质纤维化发生发展的核心环节之一。转化生长因子(TGF)-β是促EMT作用最强的细胞因子,可以启动并完成整个EMT过程,是纤维化形成与发展的启动枢纽。因此,针对TGF-β可为肾间质纤维化的防治提供新的有效途径。现就该研究方向的新进展作一综述。
Renal interstitial fibrosis（RIF） represents the final common pathology pathway of most forms of kidney disease. Epithelial-mesenehymal transition（EMT） of tubuloepithelial cells plays an important role in RIF. Although a number of factors may initiate EMT in the kidney, the most potent factor is transforming growth faetor-β （TGF-β）. That the molecular pathways for TGF-β induced EMT have critical relation with the mechanism of RIF. Such represent a potential therapeutic approach, offering a mechanism to slow or even redress established renal interstitial fibrosis. K
出处
《国际内科学杂志》
CAS
2009年第4期238-241,共4页
International Journal of Internal Medicine
关键词
肾小管上皮细胞转分化
转化生长因子Β
肾间质纤维化
Epithelial-mesenehymal transition
Transforming growth faetor-β
Renal interstitial fibrosis
