摘要
目的探讨高危型HPV-DNA检测对宫颈细胞学诊断为不典型鳞状上皮细胞不除外高度鳞状上皮内病变(ASC-H)的分流管理作用。方法对行新柏氏TCT膜式液基超薄细胞学检查,且诊断结果为ASC-H的112例患者行高危型HPV-DNA检测及阴道镜下活检。比较分析高危型HPV-DNA检测结果与病理组织学诊断结果结果112例ASC-H患者中,病理组织学结果为高级别鳞状上皮内病变以下的患者(包括CIN Ⅰ、宫颈慢性炎)检出率为34.82%(39/112)。HPV阳性时高级别鳞状上皮内病变以下的患者检出率为16.88%(13/77),HPV阴性时的检出率为74.29%(26/35);高级别鳞状上皮内病变以上的患者(包括CINⅡ-Ⅲ、宫颈癌)检出率为65.18%(73/112),HPV阳性时高级别鳞状上皮内病变以上的患者检出率为83.12%(64/77),HPV阴性时的检出率为25.71%(9/35)。HPV阴性患者检出高级别鳞状上皮内病变以下患者的概率高于HPV阳性者,差异有统计学意义(χ2=34.93,P<0.05)。结论高危型HPV-DNA检测可有效地对ASC-H患者进行分流,有利于临床对ASC-H患者采取合理有效的处理方法。
Objective To explore the distributable use of high-risk human papillomavirus （HPV） DNA testing to deal with atypical squamous cells-can-not excluding HISL. Methods Totally 112 ASC-H patients tested by liquidbased cytology were included in this study. Hybid capture II assay was applied in the high-risk HPV DNA detection. The cervical pathologic diagnoses were obtained under colposcopy guided biopsy. The results of high-risk HPV DNA detection and the pathological diagnosis were compared. Results In 112 patients of ASC-H, the detection rate of CIN I or chronic inflammation was 34.82%（39/l12）;the patients with positive HPV DNA was 16.88%（13/77） and negative was 74.29%（26/35）. The detection rate of CIN Ⅱ-Ⅲ or cervical cancer was 65.18%（73/112）; the patients with positive HPV DNA was 83.12%（64/77） and negative was 25.71%（9/35）. Detection rate of the lesion below the high squamous cell lesion in patients with negative HPV DNA was higher than that in patients with positive HPV DNA. The difference had statistic significance （X^2=34.93, P〈0.05）. Conclusion High-risk HPV-DNA testing is useful in dealing with the ASC-H patients.
出处
《全科医学临床与教育》
2009年第2期102-104,共3页
Clinical Education of General Practice
