摘要
成纤维细胞生长因子-21(fibroblast growth factor-21,FGF-21)是最近几年发现的一个不依赖胰岛素调节血糖的细胞因子,有望成为治疗2型糖尿病的备选药物。虽然该蛋白最近才进入研究人员的视野,但是关于它的分子机制和生物活性正在被快速的揭示。很多蛋白因子和信号通路已被证明参与到FGF-21生物活性当中,令我们对FGF-21的认识不断完善和更新。该文主要阐述FGF-21的作用机制和药物研究的最新进展。
Fibroblast growth factor （FGF）-21 is a novel insulinindependent glucose regulator, and can be a potential therapeutics for treatment of type Ⅱ diabetes. Although FGF-21 was discovered recently, the insight into its biology and therapeutic utility is rapidly evolving. A number of key metabolically-linked molecules and pathways have been suggested to be involved in the mechanism of action of FGF-21, which enables us to renew the understanding of the FGF-21. The aim of this review is to report the update research outcomes.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2009年第4期433-435,共3页
Chinese Pharmacological Bulletin
基金
黑龙江省科技厅重点攻关资助项目(No2006G0461-00)
