摘要
目的:优选川芎最佳超微振动提取工艺。方法:以盐酸川芎嗪和阿魏酸为测定指标,采用正交试验设计法优化超微振动提取的次数、时间和溶剂用量,并与常规乙醇回流提取工艺进行比较。结果:川芎超微振动提取最佳工艺为药材粗粉加4倍量90%的乙醇超微振动提取,室温提取2次,每次15 min。在此条件下,与常规乙醇回流提取工艺相比,提取时间缩短为原来的1/6,溶剂用量为4/7,盐酸川芎嗪和阿魏酸提取率分别为常规工艺的1.19,1.09倍。结论:超微振动提取时间短、溶剂用量少、有效成分提取率高,具有工业化推广的前景。
Objective： To explore the best ultrafine vibration extraction technology of Rhizoma Chuanxiong. Method： Using the content of ligustrazine hydrochloride and ferulic acid as determination indexes, quadrature test was used to choose extraction times, time, solvent amount and to compare with the result of conventional extraction technology. Result： The best condition of the Rhizoma chuanxiong was with 90% ethanol of 4 times volume, extracting 2 times in 25 ℃, 15 minutes each time. Comparing with conventional extraction technology, extraction time of UVET was 1/6, solvent amount was 4/7, the extraction rate of marker components was 1.19 and 1.09 times, respectivley. Conclusion ： UVET can improve the extracting rate of effective constituents, reduce the time and solvent amount and be used in industrialization.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2009年第8期977-979,共3页
China Journal of Chinese Materia Medica
基金
山东省卫生厅项目课题(2005-180)
关键词
川芎
超微粉碎
超微振动提取
工艺
Rhizoma Chuanxiong
uhrafine pulverization
ultrafine vibration extraction
technology
