摘要
A series of novel 2,4-diamino-pteridines （9a-l） were synthesized and evaluated as inhibitors of inducible nitric oxide synthase （iNOS） in vitro. It was found that 9a, 9d, 9e, 9h, 9i and 91 showed potent inhibitory activities similar to that of methotrexate （MTX）, while the activities of 9b, 9c, 9f, 9g, 9j and 9k are stronger than MTX.
A series of novel 2,4-diamino-pteridines （9a-l） were synthesized and evaluated as inhibitors of inducible nitric oxide synthase （iNOS） in vitro. It was found that 9a, 9d, 9e, 9h, 9i and 91 showed potent inhibitory activities similar to that of methotrexate （MTX）, while the activities of 9b, 9c, 9f, 9g, 9j and 9k are stronger than MTX.
